淋巴细胞DNA损伤,冠状动脉疾病和血液微量元素之间的关系
İsmail Erdoğu1, Emrah Dural2, Hüseyin Altundağ3
1Department of Cardiology, Medicana Sivas Hospital, Medicana Health Group, Sivas 58070, Turkey.
Mutagenesis
|October 11, 2023
概括
淋巴细胞DNA损伤是冠状动脉疾病 (CAD) 风险的强有力的指标,与疾病严重程度有明显的相关性. 诸如衰老,肌素和尿素水平升高等因素增加了DNA损伤和CAD风险,男性的水平高于女性.
科学领域:
- 生物化学和分子生物学
- 心血管医学 心血管医学
- 环境健康 环境健康
背景情况:
- 动脉样硬化病变与体质DNA损伤有关,但其在冠状动脉疾病 (CAD) 中的作用需要进一步阐明.
- 了解淋巴细胞DNA损伤,血液微量元素和CAD之间的相互作用对于风险评估至关重要.
研究的目的:
- 研究淋巴细胞DNA损伤,血液微量元素度和冠状动脉疾病 (CAD) 的严重程度之间的关系.
- 确定与DNA损伤和CAD严重程度相关的人口和临床因素.
主要方法:
- 采用单细胞性彗星试验来测量99名接受血管学干预的患者的淋巴细胞DNA损伤.
- 量化了14个血液微量元素度,使用诱导合的等离子体光学发射光谱学 (ICP-OES).
- 分析了DNA损伤,微量元素,语法得分和临床/人口参数之间的相关性.
主要成果:
- 淋巴细胞DNA损伤与CAD严重程度有很强的相关性 (语法得分,r=0.858,P<.001).
- DNA损伤与年龄,血尿素,肌素,HbA1c,心电图-QRS持续时间和心电图喷射率有显著的相关性.
- 与女性相比,在男性中观察到更高的DNA损伤和CAD风险;老龄化和较高的肌素/尿素与风险增加有关.
结论:
- 淋巴细胞DNA损伤作为CAD动脉样硬化指标的强有力的生物标志物.
- 衰老,肌素和尿素水平是影响DNA损伤频率和CAD风险的重要因素.
- 进一步的研究是有必要的,以充分理解微量元素,DNA损伤和CAD开发之间的复杂相互作用.
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