竞争的选择神经表示形式在人类中形成证据积累
Krista Bond1,2,3, Javier Rasero1, Raghav Madan4
1Department of Psychology, Carnegie Mellon University, Pittsburgh, United States.
eLife
|October 11, 2023
概括
在不断变化的环境中,灵活的决策依赖于适应性政策. 在皮质 - 基底 - 甲状腺电路中的多巴胺活性可塑性改变了证据流动,优化了动态环境变化期间的决策政策.
科学领域:
- 神经科学是一个神经科学.
- 计算神经科学是一种神经科学.
- 认知科学 认知科学
背景情况:
- 在动态环境中适应性决策需要灵活的政策.
- 之前的研究表明,结果的突发性转变改变了决策政策的证据积累.
研究的目的:
- 阐明通过皮质 - 基底 - 脑垂体 (CBGT) 电路实现决策政策转移的可行性.
- 调查多巴胺塑性在竞争行动表征之间重定向证据流动中的作用.
主要方法:
- 在 silico 实验中,用于产生电路机制的预测.
- 在人体参与者身上进行了活体功能磁共振成像 (fMRI) 实验.
- 使用分类器模型来衡量行动代表之间的竞争.
主要成果:
- 已被证明,当行动应急情况发生变化时,多巴胺活性可塑性会在动作表征内部和动作表征之间重新调整权力平衡.
- 当诉讼代表之间的竞争最高时,证据积累率最低.
- fMRI数据证实,血液动力学反应预测了试验明智的选择,竞争追踪了证据积累率的变化.
结论:
- 通过多巴胺活性可塑性,CBGT电路可通过多巴胺活性可塑性实现决策政策的转变.
- 行动代表团之间的竞争调节了证据积累的速度,影响了决策政策.
- 这些发现为哺乳动物CBGT电路如何适应和管理证据积累以实现灵活的决策提供了全面的理解.
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