儿科麻醉中的呼吸道局部化:一项国际横截面研究
H A Iliff1,2, A Baxter3, A Chakladar4
1Department of Anaesthesia, Cardiff and Vale University Health Board, Cardiff, UK.
Paediatric anaesthesia
|October 11, 2023
概括
目前用于儿科呼吸道局部化治疗的利多卡因剂量缺乏国际共识,全球观察到的实践差异很大. 这项研究强调了需要标准化指导方针,以确保患者的安全和预防不良事件.
科学领域:
- 麻醉学 麻醉学
- 儿科医学 儿科医学
- 药理学 药理学是指药理学的学科.
背景情况:
- 对于儿科呼吸道局部化治疗中利多卡因的剂量,目前还没有确立的国际准则.
- 在医学文献中报告的利多卡因剂量显示出相当大的变化.
研究的目的:
- 确定当前国际实践的利多卡因剂量 (毫克/千克和度) 儿科气道局部化.
- 调查儿科患者使用利多卡因相关的局部麻醉系统毒性 (LAST) 的后护指令和实例.
主要方法:
- 这是一项涉及69个国家的1501名参与者的跨部门调查研究.
- 收集关于人口统计,临床实践和局部麻醉剂系统毒性的数据.
- 基于响应率的分析,使用比例和中位数来最大限度地减少非响应错误.
主要成果:
- 在利多卡因剂量和时间方案中发现了显著的异质性.
- 报告的中位数最大剂量为5mg/kg (四分位数范围为4-6mg/kg),平均2小时.
- 有证据表明,目前的剂量做法可能会导致不良结果.
结论:
- 这些发现强调,迫切需要进一步研究和制定关于儿科呼吸道局部化利多卡因剂量的国际共识.
- 标准化的指导方针对于在这种患者群体中安全地使用利多卡因至关重要.
- 本研究旨在支持未来的合作努力,以建立最佳实践.
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