根据亚型,年龄,并发症和疫苗接种情况的流感住院负担:2012-2013年至2018-2019年季节,北克,加拿大
Sara Carazo1,2, Charles-Antoine Guay1,2,3,4, Danuta M Skowronski5
1Biological Risks Unit, Institut National de Santé Publique du Québec, Quebec City, Quebec, Canada.
概括
流感住院率在婴儿和老年人中最高,特别是那些患有并发病的人. 疫苗接种对有健康状况的老年人最有效,为有针对性的免疫策略提供了信息.
科学领域:
- 流行病学 流行病学
- 公共卫生 公共卫生
- 免疫学 免疫学 免疫学
背景情况:
- 流感免疫计划旨在减轻严重的结果.
- 了解风险因素对于优化疫苗接种策略至关重要.
- 这项研究分析了七个季节的流感住院情况.
研究的目的:
- 为最佳流感免疫计划策略提供信息.
- 为了监测流感住院情况,按年龄,并发症和疫苗接种状况分层分层.
- 为了确定受流感和疫苗接种效率影响最大的人口.
主要方法:
- 来自加拿大北克省4家医院 (2012-2019) 的数据.
- 积极监测急诊室急性呼吸道感染患者的入院情况.
- 对流感病毒的聚合酶连锁反应测试和基于人口的发病率估计.
主要成果:
- 平均季节性流感住院发生率为89/100,000.
- 在婴儿 (0-5个月) 和75岁以上的成年人中观察到的最高风险.
- 患有并发症的个人住院风险高7倍 (214对30/100,000).
- 对于伴随疾病的老年人来说,需要接种疫苗的数量明显较低.
结论:
- 严重的流感结局因亚型,年龄,并发症和疫苗接种情况而异.
- 详细的风险分层对于有效的免疫计划规划至关重要.
- 政策制定者需要这些数据来优先考虑资源以获得最大影响.
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