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Updated: Jul 13, 2025

Rare Event Detection Using Error-corrected DNA and RNA Sequencing
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错误分类错误对基于下一代测序的生物标志物的性能的影响,这是一个模拟研究

Dong Wang1, Sue-Jane Wang2, Samir Lababidi3

  • 1Division of Bioinformatics and Biostatistics, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, Arkansas, USA.

Journal of biopharmaceutical statistics
|October 11, 2023
PubMed
概括

液体活检的下一代测序 (NGS) 可以引入错误分类. 模拟表明,这种影响生物标志物的临床实用性在较低准确度的应用程序中更大,尤其是机器学习分类器.

关键词:
循环瘤DNA是循环中的瘤DNA.液体活检活检液体活检机器学习是机器学习.错误的分类错误是一个错误的分类错误.这是下一代测序.精准医学是一门精准医学.

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Organisms are capable of detecting and fixing nucleotide mismatches that occur during DNA replication. This sophisticated process requires identifying the new strand and replacing the erroneous bases with correct nucleotides. Mismatch repair is coordinated by many proteins in both prokaryotes and eukaryotes.
The Mutator Protein Family Plays a Key Role in DNA Mismatch Repair
The human genome has more than 3 billion base pairs of DNA per cell. Prior to cell division, that vast amount of genetic...
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