使用贝叶斯式基于intravoxel的不连贯运动扩散加权成像来量化肝功能的非对比方法:试点研究
Monchai Phonlakrai1,2, Saadallah Ramadan3,4, John Simpson5,6
1School of Health Sciences, College of Health, Medicine and Wellbeing, The University of Newcastle, Newcastle, NSW, Australia.
Journal of applied clinical medical physics
|October 11, 2023
概括
输入素不连贯的运动扩散加权成像 (IVIM-DWI) 显示出评估肝功能的前景. 伪扩散 (Dfast) 和 perfusion 分数 (Fp) 等参数可以在全球和 voxel 水平上检测肝功能障碍.
科学领域:
- 放射学和医学成像学 医学成像学
- 肝病学 肝病学是一种肝病学.
- 生物物理学的生物物理.
背景情况:
- 肝硬化会损害肝功能和输液,可通过MRI检测.
- 使用13-b值的intravoxel不连贯运动扩散权重成像 (IVIM-DWI) 对肝功能水平的评估可以改善早期损伤的肝节约放射治疗.
研究的目的:
- 评估IVIM-DWI的可行性,以评估voxel水平的肝功能.
- 为了将IVIM-DWI发现与其他多参数 (mp) MRI方法相关联.
主要方法:
- 从IVIM-DWI的13-b值和B1-校正的双翻角 (DFA) T1映射中研究了明显扩散系数 (ADC) 的变化.
- 获取的mp-MRI数据包括IVIM-DWI,T1地图和低时间分辨率动态对比增强 (LTR-DCE) MRI用于肝部提取分数 (HEF) 地图生成.
- 使用曼-惠特尼U测试的健康志愿者和患者之间的IVIM-DWI参数 (Dslow, Dfast, Fp) 的比较;使用皮尔森相关性评估患者的HEF,T1和IVIM参数之间的voxel水平相关性.
主要成果:
- 在体外测量显示,ADC的最大变化系数为12.4%,T1.1.的最大变化系数为16.1%.
- 在全球范围内,Fp和Dfast区分健康与轻度肝功能受损 (Fp的p=0.002,Dfast的p<0.001).
- 在患者中,FP和DFast显示了中度的voxel水平与HEF相关性.
结论:
- Dfast和FP显示了检测肝功能障碍的潜力.
- 这些参数在肝功能评估的全球和像素水平上都有效.
相关概念视频
Assessment of Diffusion and Perfusion
992
Understanding and evaluating diffusion and perfusion is critical in assessing a patient's respiratory and circulatory health. These processes play key roles in maintaining the body's internal environment, ensuring that tissues receive adequate oxygen while waste products are efficiently removed.
The Role of Diffusion in Respiration
Diffusion is the process by which molecules move from an area of higher concentration to an area of lower concentration. In the respiratory system, this...
The Role of Diffusion in Respiration
Diffusion is the process by which molecules move from an area of higher concentration to an area of lower concentration. In the respiratory system, this...
992
Magnetic Resonance Imaging
5.2K
Magnetic resonance imaging (MRI) is a noninvasive medical imaging technique based on a phenomenon of nuclear physics discovered in the 1930s, in which matter exposed to magnetic fields and radio waves was found to emit radio signals. In 1970, a physician and researcher named Raymond Damadian noticed that malignant (cancerous) tissue gave off different signals than normal body tissue. He applied for a patent for the first MRI scanning device in clinical use by the early 1980s. The early MRI...
5.2K
Imaging Studies for Cardiovascular System IV: CMRI
38
Cardiovascular magnetic resonance imaging, or CMRI, is a non-invasive diagnostic test that employs a magnetic field and radiofrequency waves to create precise images of the heart and arteries. It provides comprehensive information about cardiac anatomy, function, perfusion, and tissue characterization without ionizing radiation.IndicationsCMRI diagnoses various heart conditions, including tissue damage from heart attacks, ischemic heart disease, myocarditis, aortic issues (tears, aneurysms,...
38
Imaging Studies VII: Vascular Imaging
14
DefinitionRenal angiography, also known as renal arteriography, is an imaging technique used to obtain a comprehensive view of blood flow and the vascular structure of blood vessels in the kidneys and surrounding areas.PurposeRenal angiography detects blood vessel abnormalities in the kidneys, such as aneurysms, stenosis, thrombosis, vascular tumors, and renal artery stenosis. It evaluates kidney function and guides interventional treatments like angioplasty or stent placement.Pre-Procedure...
14


