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使用贝叶斯式基于intravoxel的不连贯运动扩散加权成像来量化肝功能的非对比方法:试点研究

Monchai Phonlakrai1,2, Saadallah Ramadan3,4, John Simpson5,6

  • 1School of Health Sciences, College of Health, Medicine and Wellbeing, The University of Newcastle, Newcastle, NSW, Australia.

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概括
此摘要是机器生成的。

输入素不连贯的运动扩散加权成像 (IVIM-DWI) 显示出评估肝功能的前景. 伪扩散 (Dfast) 和 perfusion 分数 (Fp) 等参数可以在全球和 voxel 水平上检测肝功能障碍.

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在DCE-MRI中,使用的是DCE-MRI.在HCC中,HCC是HCC,HCC是HCC.T1映射 T1映射 T1映射 T1映射intravoxel不连贯的运动扩散.肝硬化是肝硬化的一种疾病.肝功能 肝功能 肝功能

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科学领域:

  • 放射学和医学成像学 医学成像学
  • 肝病学 肝病学是一种肝病学.
  • 生物物理学的生物物理.

背景情况:

  • 肝硬化会损害肝功能和输液,可通过MRI检测.
  • 使用13-b值的intravoxel不连贯运动扩散权重成像 (IVIM-DWI) 对肝功能水平的评估可以改善早期损伤的肝节约放射治疗.

研究的目的:

  • 评估IVIM-DWI的可行性,以评估voxel水平的肝功能.
  • 为了将IVIM-DWI发现与其他多参数 (mp) MRI方法相关联.

主要方法:

  • 从IVIM-DWI的13-b值和B1-校正的双翻角 (DFA) T1映射中研究了明显扩散系数 (ADC) 的变化.
  • 获取的mp-MRI数据包括IVIM-DWI,T1地图和低时间分辨率动态对比增强 (LTR-DCE) MRI用于肝部提取分数 (HEF) 地图生成.
  • 使用曼-惠特尼U测试的健康志愿者和患者之间的IVIM-DWI参数 (Dslow, Dfast, Fp) 的比较;使用皮尔森相关性评估患者的HEF,T1和IVIM参数之间的voxel水平相关性.

主要成果:

  • 在体外测量显示,ADC的最大变化系数为12.4%,T1.1.的最大变化系数为16.1%.
  • 在全球范围内,Fp和Dfast区分健康与轻度肝功能受损 (Fp的p=0.002,Dfast的p<0.001).
  • 在患者中,FP和DFast显示了中度的voxel水平与HEF相关性.

结论:

  • Dfast和FP显示了检测肝功能障碍的潜力.
  • 这些参数在肝功能评估的全球和像素水平上都有效.