LncRNADisease v3.0:长非编码RNA相关疾病的最新数据库
Xiao Lin1, Yingyu Lu1, Chenhao Zhang1
1Department of Biomedical Informatics, Center for Noncoding RNA Medicine, State Key Laboratory of Vascular Homeostasis and Remodeling, School of Basic Medical Sciences, Peking University, 38 Xueyuan Rd, Beijing 100191, China.
Nucleic acids research
|October 11, 2023
概括
更新的LncRNADisease v3.0数据库现在包括超过25,000个经过实验支持的长非编码RNA (lncRNA) 和循环RNA (circRNA) 疾病关联. 这个资源有助于理解RNARNA.
科学领域:
- 分子生物学分子生物学
- 基因组学就是基因组学.
- 生物信息学是一种生物信息学.
背景情况:
- 长非编码RNA (lncRNA) -疾病关联的系统整合对于理解分子机制至关重要.
- 识别基于 lncRNA 的生物标志物和治疗方法需要全面的数据.
- 在LncRNADisease数据库作为一个资源为lncRNA疾病协会.
研究的目的:
- 更新和扩展LncRNADisease数据库,以精选的lncRNA和循环RNA (circRNA) 疾病关联.
- 为实验支持的协会提供信心评分.
- 将关联分为一般类型和因果类型,以获得更深入的见解.
主要方法:
- 来自科学文献的精选综合 lncRNA (包括 circRNA) 和疾病关联.
- 根据实验证据,为每个 lncRNA-疾病对分配了信心评分.
- 将关联分为一般和因果类别.
主要成果:
- LncRNADisease v3.0包含25440个经过实验支持的关联,比上一个版本增加了两倍多.
- 确定了15721个一般关联和9719个因果关联.
- 一个案例研究表明了数据库在计算人类和小鼠 lncRNAs之间的表型相似性方面的实用性.
结论:
- LncRNADisease v3.0是一个显著扩展和宝贵的资源,用于lncRNA和circRNA研究.
- 该数据库支持探索lncRNA/circRNA在疾病发病过程中的作用.
- 它作为潜在的临床应用和生物标志物发现的基础.
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