变体3.0:药物载体的表型和调控变异性
Jiayi Yin1,2, Zhen Chen1, Nanxin You1
1College of Pharmaceutical Sciences, Department of Clinical Pharmacy, The First Affiliated Hospital, Zhejiang University School of Medicine, National Key Laboratory of Advanced Drug Delivery and Release Systems, Zhejiang University, Hangzhou 310058, China.
Nucleic acids research
|October 11, 2023
概括
VARIDT 3.0 现在全面列出了药物载体 (DT) 的变异性,包括微生物群的影响,转录性,表观遗传性,外源性和后翻译性修改. 这个更新的数据库有助于理解药物反应和优化ADME属性.
科学领域:
- 药理学和药物新陈代谢
- 生物信息学和计算生物学
背景情况:
- 药物载体 (DT) 变异性显著影响药物反应,药物相互作用和多药物耐药性.
- 影响DT变化的关键因素包括微生物群影响 (MBI),转录调节 (TSR),表观遗传调节 (EGR),外源调制 (EGM) 和翻译后修饰 (PTM).
- 现有的数据库缺乏关于这些关键的DT变量的全面信息.
研究的目的:
- 进行VARIDT数据库的重大更新,为DT变化提供一个集中资源.
- 促进人们更深入地了解各种监管机制如何影响药物输送器功能.
- 通过整合各种变异性数据,支持药理动力学和药理动力学方面的研究.
主要方法:
- 数据库的更新和扩展,包括MBI,TSR,EGR,EGM和PTM的新数据.
- 数据整合和策划以确保准确性和全面性.
- 对已批准和临床试验药物的药物运输的变异性数据的关联分析.
主要成果:
- 更新后的VARIDT 3.0数据库包含了大量的数据:2072个MBI,10610个TSR,46,748个EGR,12209个EGM和10,255个PTM.
- 可变性数据与585种已批准的和301种临床试验药物在572种疾病中联系在一起.
- 一个重要的发现是,大多数DT表现出多种类型的可变性,使ADME属性确定能够进行集体考虑.
结论:
- VARIDT 3.0为药物载体的变异性提供了一个全面的资源,这对于理解药物行为至关重要.
- 该数据库使药物吸收,分布,新陈代谢和分泌 (ADME) 属性的评估能够采用整体方法.
- VARIDT 3.0是免费访问的,可以作为现有的制药数据库的宝贵补充.
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