阿根廷的抗治疗抑郁症:TRAL研究的纵向分析结果
Christian Lupo1, Gerardo García Bonetto2, Ricardo Marcelo Corral3
1Médica psiquiatra; Directora CIAP, Rosario, Provincia de Santa Fe, Argentina. gkanevsk@its.jnj.com.
Vertex (Buenos Aires, Argentina)
|October 11, 2023
概括
阿根廷的治疗耐药抑郁症 (TRD) 结果显示,尽管有标准护理 (SOC),但缓解率有限,持续残疾严重. 需要进一步努力,以改善TRD治疗方案和该地区患者的治疗结果.
科学领域:
- 精神病学是一个精神病学.
- 临床心理学 临床心理学
- 公共卫生 公共卫生
背景情况:
- 阿根廷关于治疗耐药抑郁症 (TRD) 结果和患者报告的结果 (PRO) 的文献有限.
- 拉丁美洲治疗耐药抑郁症 (TRAL) 研究此前已经确定了该地区的TRD负担.
研究的目的:
- 报告阿根廷TRD患者的1年标准护理 (SOC) 结果.
- 分析治疗反应,缓解率和患者报告的结果 (PRO),包括生活质量 (QoL) 和残疾.
主要方法:
- 分析了阿根廷5个地点的220名主要抑郁症 (MDD) 患者中72名TRD患者的子样本.
- 排除标准包括精神病,精神分裂症,双相情感障碍,精神分裂情感障碍,痴呆症,严重的化学依赖或同时参加试验.
- 结果措施包括MADRS,PHQ-9,EQ-5D (生活质量) 和SDS (残疾).
主要成果:
- 61%的TRD患者实现了临床反应 (≥50%的MADRS减少),但超过33%的患者没有达到缓解 (MADRS ≤12).
- 患者报告的重大残疾持续存在,影响工作/学校 (71%),社会生活 (69.7%) 和家庭责任 (66.6%).
- 近67%的患者报告了持续的焦虑/抑郁症状 (EQ-5D).
结论:
- 在阿根廷,TRD给阿根廷患者带来了巨大的负担.
- 当前的标准护理 (SOC) 给出了低于最佳的缓解和功能结果.
- 加强治疗方案是必要的,以改善阿根廷TRD患者的治疗结果.
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