单次低剂量计算机断层扫描查肺癌的有效性:中国的一项基于人口的透视队列研究
Zhifu Yu1, Ping Ni1, Huihui Yu1
1Liaoning Office for Cancer Control and Research, Cancer Hospital of China Medical University, Liaoning Cancer Hospital and Institute, Shenyang, Liaoning, China.
International journal of cancer
|October 11, 2023
概括
在中国,低剂量计算机断层扫描 (LDCT) 查肺癌显著降低了肺癌死亡率31%,全因死亡率23%. 这种查方法在降低中国人口死亡率方面是有效的.
科学领域:
- 在瘤学瘤学.
- 公共卫生 公共卫生
- 放射学 放射学是一门学科.
背景情况:
- 肺癌在全球范围内仍然是一个重大的健康问题,特别是在中国.
- 通过查进行早期检测对于改善患者的治疗结果和降低死亡率至关重要.
- 在不同人群中低剂量计算机断层扫描 (LDCT) 查的有效性需要持续评估.
研究的目的:
- 评估低剂量计算机断层扫描 (LDCT) 查肺癌在中国的有效性.
- 评估LDCT查对肺癌发病率,死亡率和全因死亡率的影响.
- 分析来自中国城市癌症查计划 (CanSPUC) 的查数据.
主要方法:
- 采用了视角队列研究设计.
- 从2012年到2019年,分析了40-74岁的参与者.
- 逆概率加权 (IPW) 和考克斯比例危险模型被用于调整分析.
主要成果:
- 一次LDCT扫描增加了37.0%的肺癌发病率密度 (HR 1.37).
- LDCT查显著降低了 31.0% (HR 0.69) 的肺癌死亡率.
- 在查组中,所有原因死亡率显著降低了23.0% (HR 0.77).
结论:
- 一次低剂量计算机断层扫描 (LDCT) 查有效降低了中国的肺癌死亡率.
- 最不发达国家人群查也导致所有原因死亡率显著下降.
- 这些发现支持在中国实施LDCT肺癌查计划.
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