关于功能性葡萄糖生物酶的特性,生产和应用的综合性审查
Shuqi Zhang1, Dawei Ni1, Yingying Zhu1
1State Key Laboratory of Food Science and Resoruces, Jiangnan University, Wuxi, Jiangsu, China.
Critical reviews in food science and nutrition
|October 11, 2023
概括
葡萄糖生物酶,葡萄糖的二糖化物,由于不同的甘油酸键,其结构和功能各不相同. 生物合成提供了一种可行的方法,用于生产具有显著健康益处的罕见葡萄糖.
科学领域:
- 碳水化合物化学 碳水化合物化学
- 生物技术是生物技术.
- 食品科学 食品科学 食品科学
背景情况:
- 葡萄糖生物体是由两个葡萄糖单元组成的脱糖体,其糖键的变化导致了不同的结构和特性.
- 虽然像马尔托斯这样的常见葡萄糖有有限的已知的健康作用,但更罕见的形式表现出显著的生物效应.
- 从自然来源提取罕见的葡萄糖通常是不切实际的,强调了需要替代生产方法.
研究的目的:
- 提供葡萄糖的综合性审查,涵盖其自然发生,物理化学特征和生物功能.
- 总结基于酶和发酵的葡萄糖生产方法.
- 探索葡萄糖生物酶在各种领域的多样化应用.
主要方法:
- 关于葡萄糖菌病的科学出版物的文献综述.
- 分析有关葡萄糖的结构,特性和生物活动的数据.
- 收集有关生产技术的信息,包括酶合成和发酵.
主要成果:
- 详细概述葡萄糖生物质的多样性,包括三糖,麦芽糖和蜂糖,重点关注由甘酸键赋予的结构差异.
- 关键的物理化学性质的总结,如甜度,消化性,毒理学和造性.
- 用于生产葡萄糖的特定酶和发酵过程的目录.
- 探索不同葡萄糖生物的多功能功能和广泛应用.
结论:
- 葡萄糖生物体代表了一组多样化的碳水化合物,具有显著的潜力,特别是罕见的形式.
- 生物合成是生产有价值的葡萄糖生物的一个有希望和可行的方法.
- 对葡萄糖生产和应用的进一步研究可以释放其在健康和工业中的全部潜力.
相关概念视频
Oral Hypoglycemic Agents: α-Glucosidase Inhibitors
185
α-glucosidase inhibitors, including acarbose (Precose), miglitol (Glyset), and voglibose (Voglib) (primarily available in Asia), are drugs that control blood sugar levels by delaying the digestion of starch and disaccharides. They achieve this by inhibiting α-glucosidase enzymes in the intestine, which slow the absorption of carbohydrates in the intestine, which in turn leads to a prolonged release of the glucoregulatory hormone GLP-1 from intestinal L-cells.
Acarbose and miglitol are...
Acarbose and miglitol are...
185
Biosynthesis of Polysaccharides
19
Polysaccharides such as glycogen and starch are synthesized from nucleoside diphosphate sugars, primarily uridine diphosphate glucose (UDPG) and adenosine diphosphate glucose (ADPG). These activated glucose donors act as key intermediates in carbohydrate metabolism and biosynthesis. UDPG primarily involves glycogen synthesis in animals and many bacteria, while ADPG plays a fundamental role in starch synthesis in plants and certain bacteria.UDPG is formed when glucose-1-phosphate reacts with...
19
Protein Glycosylation
7.0K
Glycosylation, the most common post-translational modification for proteins, serves diverse functions. Adding sugars to proteins makes the proteins more resistant to proteolytic digestion. Glycosylated proteins can act as markers and receptors to promote cell-cell adhesion. Additionally, they have many essential quality control functions in the cell, such as correct protein folding and facilitating transport of misfolded proteins to the cytosol, which can be degraded.
Glycosylation occurs in...
Glycosylation occurs in...
7.0K
Glucose Transporters
22.8K
Glucose transporters facilitate the transport of glucose across the cell membrane. In addition to glucose, some glucose transporters can also aid the movement of other hexoses such as fructose, mannose, and galactose.
Facilitated diffusion-glucose transporters (GLUTs) are encoded by the solute-linked carrier (SLC) family 2, subfamily A gene family, or SLC2A. The 14 GLUT protein members are distributed into three classes:
Facilitated diffusion-glucose transporters (GLUTs) are encoded by the solute-linked carrier (SLC) family 2, subfamily A gene family, or SLC2A. The 14 GLUT protein members are distributed into three classes:
22.8K
Overview of Carbohydrate Metabolism
1.1K
Carbohydrate metabolism is a fundamental biochemical process that ensures a constant supply of energy to living cells. The most important carbohydrate is glucose, which can be broken down via glycolysis to enter into the Krebs cycle and eventually lead to the production of ATP through oxidative phosphorylation.
Glucose transport into cells is facilitated by a family of transport proteins called GLUT (Glucose Transporters). GLUT4 is the primary glucose transporter for insulin-stimulated glucose...
Glucose transport into cells is facilitated by a family of transport proteins called GLUT (Glucose Transporters). GLUT4 is the primary glucose transporter for insulin-stimulated glucose...
1.1K
Hormones Regulating Blood Glucose
3.4K
Insulin is released by beta cells of the pancreas when blood glucose levels are high. It facilitates glucose absorption and utilization in insulin-dependent cells with insulin receptors on their plasma membranes. Insulin promotes glucose uptake by increasing the number of glucose transport proteins in the cell membrane, allowing glucose to enter the cell. As a result, glucose utilization and ATP production are enhanced.
In addition to accelerating glucose uptake and utilization, insulin has...
In addition to accelerating glucose uptake and utilization, insulin has...
3.4K


