整个大脑灰质成熟轨迹与自闭症特征相关,从青春期到成年早期
Guillaume Gros1,2, Ruben Miranda Marcos1,2, Anthony Latrille3
1Control-Interoception-Attention Team, Hôpital Pitié-Salpêtrière Paris, Brain Institute, Inserm/CNRS/Sorbonne University, UMR 7225/U1127, Paris, France.
Brain structure & function
|October 11, 2023
概括
青少年的自闭症特征与大脑成熟的差异有关,特别是在年轻女性中. 这些发现表明性别特定的大脑发育轨迹和女性潜在的保护机制.
科学领域:
- 神经科学是一个神经科学.
- 发展心理学 发展心理学
- 遗传学 是一个遗传学.
背景情况:
- 在一般人群中存在自闭症特征.
- 青春期的大脑成熟是一个关键的发展时期.
- 性对自闭症特征相关的大脑发育的影响还不太清楚.
研究的目的:
- 调查自闭症特征与青少年长度灰色物质 (GM) 成熟轨迹之间的关联.
- 探索性对这些大脑成熟轨迹的影响.
主要方法:
- 对709名青少年 (14至22岁) 的长度评估.
- 基于voxel的形态测量来分析灰色物质体积变化.
- 社会响应度量 (SRS) 用于测量自闭症特征和子分数.
主要成果:
- 在女性中,更高的自闭症特征 (SRS得分) 与更慢的GM体积下降相关,在全球和特定的大脑区域 (例如,近海马体,圈).
- 社会沟通和社会认知的子得分显示了与女性转基因成熟的明显区域关联.
- 在男性中没有发现显著的纵向关联.
结论:
- 青少年女性的自闭症特征与不同的大脑成熟轨迹有关,特别是在社会大脑和奖励电路区域.
- 这些发现支持了自闭症特征个体早期灰质成熟的假设,以及女性潜在的保护机制.
- 对自闭症谱系障碍中性别特定的大脑轨迹的进一步研究是有必要的.
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