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低血症与高血症结合,会损害肌肉细胞在体外的分化

V M Bimonte¹, G Catanzaro², Z Spinello²

¹Department of Movement, Human and Health Sciences, University of Foro Italico, Largo Lauro De Bosis 6, 00195, Rome, Italy.

Journal of endocrinological investigation

|October 11, 2023

概括

甲状腺功能低下症患者由于低和高的肌肉问题而经历肌肉问题. 这项研究发现,这些情况会损害肌肉细胞分化和信号通路,这可能解释了持续的症状.

科学领域:

内分泌学在内分泌学.
细胞生物学细胞生物学
肌肉生理学肌肉生理学

背景情况:

甲状腺功能低下症的特征是甲状腺侧腺激素 (PTH) 的低水平,导致低血和高血.
临床表现主要涉及神经肌肉症状,但细胞效应尚不清楚.
了解这些效应对于治疗偏偏甲状腺症患者的持续症状至关重要.

研究的目的:

为了研究体外低血症和高血症对肌肉细胞分化的影响.
评估这些生化变化对关键肌肉分化标记物和信号通路的影响.

主要方法:

在C2C12肌肉细胞在模仿偏偏甲状腺症的条件下分化:缺血和不同程度的高酸血.
评估细胞分化标志物 (MyoD,myogenin,MHC) 和基因/蛋白质表达 (IGF-1,ERK酸化).

主要成果:

结合的低血和高血显著降低了多达50%的分化标志物 (MyoD,myogenin,MHC).
这种情况还降低了胰岛素样生长因子-1 (IGF-1) mRNA表达,并抑制了IGF信号传递.
在这些条件下,ERK酸化在分化骨肌细胞中显著降低.

结论:

低血症和高血症在体外显著改变了骨肌肉细胞的分化.
观察到肌源性标记物和信号通路 (IGF-1,ERK) 的减少可能导致低副甲状腺症的持续症状.
这些发现突出了潜在的细胞机制,这些机制是低甲状腺症神经肌肉并发症的基础.

关键词:

过高酸盐血症是什么过低血症的情况.甲状腺功能下降症甲状腺功能下降症胰岛素类生长因子-1 这是Myotube的内容.骨肌的细胞是骨肌的细胞.

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