Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Multiple Sclerosis l: Introduction01:19

Multiple Sclerosis l: Introduction

Multiple sclerosis is a chronic autoimmune disease of the central nervous system (CNS) that affects the brain, spinal cord, and optic nerves. It is an inflammatory demyelinating disorder and a leading cause of neurological disability in young adults.EpidemiologyMS commonly begins between 20 and 40 years of age and is twice as common in women. Its exact cause remains unclear, but genetic susceptibility contributes, with higher risk in first-degree relatives and identical twins. A greater...

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Correction: Stability in Cognition and Employment in People with Relapsing Multiple Sclerosis Treated with Cladribine Tablets: Two‑year Phase IV CLARIFY‑MS Study.

Neurology and therapy·2026
Same author

Normative T<sub>1</sub> and T<sub>2</sub> Brain Atlases Across the Adult Lifespan in a Chinese Cohort: Multicenter Quantitative MRI Benchmarks for Ageing and Neurodegenerative Research.

Human brain mapping·2026
Same author

Exploring an integrated group psychotherapy-exercise program for multiple sclerosis: a non-randomized pilot study.

Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·2026
Same author

Adherence to risk minimization measures for alemtuzumab use in multiple sclerosis: a drug utilization study in four European countries.

Therapeutic advances in neurological disorders·2026
Same author

Healthy knee cartilage T2 mapping assessed with GRAPPATINI and multi-echo spin-echo (MESE) at 3T: regional values, longitudinal repeatability and method agreement.

Quantitative imaging in medicine and surgery·2026
Same author

Reducing Noise Induced by Cardiac Pulsatility in Brain Maps of R<sub>2</sub>* and Magnetic Susceptibility Using Tailored k-space Sampling.

NMR in biomedicine·2026

相关实验视频

Updated: Jun 9, 2026

The Multiple Sclerosis Performance Test MSPT: An iPad-Based Disability Assessment Tool
11:35

The Multiple Sclerosis Performance Test MSPT: An iPad-Based Disability Assessment Tool

Published on: June 30, 2014

58.0K

管道微结构分析提供了有关早期多发性硬化症当前和未来残疾的信息.

Veronica Ravano1,2,3, Gian Franco Piredda4,5,6, Jan Krasensky7

  • 1Advanced Clinical Imaging Technology, Siemens Healthineers International AG, Lausanne, Switzerland. veronica.ravano@epfl.ch.

Journal of neurology
|October 11, 2023
PubMed
概括

定量核磁共振显示,白质 (WM) 管道的微结构变化预测了早期多发性硬化症 (MS) 患者的未来残疾,为监测疾病进展提供了一种新方法.

关键词:
脱叶林性疾病是一种脱叶林性疾病.磁共振成像技术 磁共振成像技术多发性硬化症是多发性硬化症.放松计放松计放松计.白质是白质的组成部分.

更多相关视频

Comprehensive Autopsy Program for Individuals with Multiple Sclerosis
09:41

Comprehensive Autopsy Program for Individuals with Multiple Sclerosis

Published on: July 19, 2019

11.5K
Magnetic Resonance Imaging of Multiple Sclerosis at 7.0 Tesla
08:51

Magnetic Resonance Imaging of Multiple Sclerosis at 7.0 Tesla

Published on: February 19, 2021

9.0K

相关实验视频

Last Updated: Jun 9, 2026

The Multiple Sclerosis Performance Test MSPT: An iPad-Based Disability Assessment Tool
11:35

The Multiple Sclerosis Performance Test MSPT: An iPad-Based Disability Assessment Tool

Published on: June 30, 2014

58.0K
Comprehensive Autopsy Program for Individuals with Multiple Sclerosis
09:41

Comprehensive Autopsy Program for Individuals with Multiple Sclerosis

Published on: July 19, 2019

11.5K
Magnetic Resonance Imaging of Multiple Sclerosis at 7.0 Tesla
08:51

Magnetic Resonance Imaging of Multiple Sclerosis at 7.0 Tesla

Published on: February 19, 2021

9.0K

科学领域:

  • 神经成像是一种神经成像.
  • 神经学 神经学
  • 生物标志物 生物标志物

背景情况:

  • 多发性硬化症 (MS) 的微观结构特征比传统的成像生物标志物更好地预测残疾.
  • 定量MRI有效地检测到脑损伤和看起来正常的组织中的微观结构变化.
  • 沿着特定的神经元通路的微观结构变化的影响仍未得到充分研究.

研究的目的:

  • 为了研究在白质 (WM) 带沿线检测到的定量MRI组织变化的程度和位置.
  • 为了将这些微观结构变化与MS患者的横截面残疾和未来残疾进展相关联.

主要方法:

  • 与规范性数据相比,在99名多发性硬化症患者中量化了voxel-wise T1变化.
  • 提取了WM管道的组织变化指标 (损伤和看起来正常的WM).
  • 进行了WM通道指标和横截面/演变残疾之间的相关性.

主要成果:

  • 在早期的多发性硬化症中,看起来正常的WM的T1变化与残疾演变相比,与横截面残疾更好地相关.
  • 在上道上发生的损伤与当前的残疾更为相关;下道变化预测了未来的残疾.
  • 在渐进性多发性硬化症中,所有WM途径都对残疾有着相似的贡献,对残疾演变的相关性很差.

结论:

  • 特定WM通路的微观结构变化预测早期MS的未来残疾,支持疾病监测的通道分析.
  • 该技术在临床上可行的扫描时间内提供WM通道特定的微观结构见解,而不需要先进的扩散成像.