环RNAs在调节瘤微环境中的作用
Tao Liu1, Kaijun Long1, Zhengfeng Zhu1
1Department of Thoracic Surgery, Affiliated Hospital of Zunyi Medical University, 149 Dalian Road, Zunyi, 563000, Guizhou, China.
Medical oncology (Northwood, London, England)
|October 11, 2023
概括
循环RNAs (circRNAs) 是瘤微环境 (TME) 中的关键调节者,影响癌症生长和转移. 这篇评论探讨了它们在血管生成,矩阵重塑和免疫抑制中的作用,强调了用于癌症治疗的TME调制.
科学领域:
- 分子生物学分子生物学
- 在瘤学瘤学.
- 生物化学 生物化学
背景情况:
- 循环RNAs (circRNAs) 是普遍存在的非编码RNAs,在真核细胞中具有很大程度上尚未探索的功能.
- 虽然已知的circRNAs作为microRNA海绵,结合RNA结合蛋白或作为转录因子,但它们在癌症中的作用正在扩大.
- 瘤生长是复杂的,受瘤微环境 (TME) 的影响,超出了基因突变.
研究的目的:
- 审查TME中circRNAs的多方面的作用.
- 阐明circRNAs如何调节瘤进展的关键方面,包括血管新生,矩阵重塑和免疫抑制.
- 讨论缺氧和共生微生物对circRNA产生的影响及其对TME的影响.
主要方法:
- 对癌症中circRNAs当前研究的文献综述.
- 对circRNA调节机制的分析 (例如,miRNA海绵,蛋白质结合).
- 检查TME组件和过程中circRNA参与的情况.
主要成果:
- 循环RNA在TME内显著调节血管生成,矩阵重塑和免疫抑制.
- 缺氧和开始性微生物被确定为circRNA生产的调节器,影响瘤生长.
- 循环RNAs通过TME调节参与瘤生长和转移.
结论:
- 通过circRNAs调节TME为癌症提供了一个有前途的治疗策略.
- 进一步研究circRNA功能及其在TME中的相互作用对于开发新型癌症治疗至关重要.
- 了解circRNA动态可以了解瘤进展和潜在的干预点.
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