通过重大抑郁状态使用lysergic酸二甲基胺
Claire A Walsh1, Lauren Gorfinkel2, Dvora Shmulewitz1,3
1Department of Translational Epidemiology, New York State Psychiatric Institute, New York.
JAMA psychiatry
|October 11, 2023
概括
过去一年的lysergic acid diethylamide (LSD) 使用在患有严重抑郁症的成年人中比没有抑郁症的成年人增加了显著. 这一趋势在年轻人和收入较低的人群中最为明显.
科学领域:
- 精神病学是一个精神病学.
- 流行病学 流行病学
- 药物使用研究 药物使用研究
背景情况:
- 对治疗抑郁症的幻觉剂的临床兴趣正在增长.
- 这可能会影响公众对lysergic acid diethylamide (LSD) 等物质的看法和使用.
研究的目的:
- 检查过去一年非医疗LSD使用的趋势.
- 为了比较患有和没有严重抑郁症的成年人之间的这些趋势.
- 通过社会人口统计学因素分析变化.
主要方法:
- 利用了国家药物使用和健康调查 (2008-2019) 中的478,492名成年人的综合数据.
- 使用后勤回归来分析基于抑郁状态的LSD使用时间趋势.
- 对社会人口统计学子组变化的二次分析.
主要成果:
- 在2008年至2019年期间,在患有严重抑郁症 (0.5%至1.8%) 的成年人中,LSD的使用在过去一年中比没有 (0.2%至0.8%) 的成年人增加了显著.
- 这种差异在年轻人 (18-34岁) 和年收入低于75,000美元的人群中最大.
- 在18-25岁的抑郁成年人中,LSD使用的患病率差异为3.3%.
结论:
- 美国患有抑郁症的成年人显示,从2008年至2019年,去年LSD使用量不成比例增加.
- 年轻的成年人和低收入的抑郁症患者表现出最显著的增长.
- 临床医生应针对使用LSD在医疗监督之外的抑郁症患者的危害降低和益处最大化.
相关概念视频
01:23Antidepressant Drugs: MAOIs and Other Agents
256
Atypical antidepressants, including bupropion (Wellbutrin), mirtazapine (Remeron), nefazodone (Serzone), trazodone (Desyrel), and vilazodone (Viibryd), offer unique mechanisms of action. Bupropion weakly inhibits dopamine and norepinephrine reuptake, aiding depression treatment and smoking cessation, with a low risk of sexual dysfunction. Mirtazapine enhances serotonin and norepinephrine neurotransmission, leading to sedation, increased appetite, and weight gain. As a result, it helps treat...
256
01:30Electroconvulsive Therapy
48
Electroconvulsive therapy (ECT), or shock therapy, remains a critical biomedical intervention for severe, treatment-resistant depression. While its origins can be traced back to Hippocrates' observations that malaria-induced convulsions alleviated mental illness, modern ECT has evolved significantly from its earlier, more primitive applications. First introduced in 1938 by Ugo Cerletti and his colleagues, ECT involves inducing controlled seizures using electrical currents. In its early...
48
01:27Hallucinogens and Psychedelics
185
Hallucinogens are psychoactive substances that profoundly alter perceptual experiences, generating unreal visual and sensory images. Often referred to as psychedelic drugs — a term derived from the Greek words "psyche" (mind) and "delos" (revealing) — these substances include marijuana and lysergic acid diethylamide (LSD), among others. These drugs vary in intensity and effects.
Marijuana, derived from the dried leaves and flowers of the hemp plant, contains...
Marijuana, derived from the dried leaves and flowers of the hemp plant, contains...
185
01:22CNS Stimulants: Psychedelic Agents
160
Hallucinogens, also known as psychedelic drugs, are a class of substances known for their ability to alter perception, cognition, and emotions. Despite their profound effects on the mind, these drugs are non-addictive, setting them apart from many other abused substances. The mechanism of action of these drugs lies in their impact on the 5-HT2A receptor in the brain. Upon activation, this receptor couples to Gq-type G proteins, triggering a cascade that releases intracellular calcium. This...
160
01:25Antidepressant Drugs: Overview
527
Antidepressant drugs are a class of medications primarily used for treating various mood disorders, including major depression, anxiety disorders, and other related conditions. These medicines work by modulating the neurotransmitter balance within the brain, alleviating depressive symptoms. Antidepressants can be broadly categorized into several groups according to their mechanism of action and chemical structure: Selective Serotonin Reuptake Inhibitors (SSRIs), Serotonin-Norepinephrine...
527
01:28Drug Therapy
49
The advent of drug therapy has profoundly shaped modern mental health care, providing targeted treatments for a range of psychological disorders. Psychotherapeutic drugs, classified into antianxiety, antidepressant, and antipsychotic medications, address symptoms across anxiety disorders, mood disorders, and schizophrenia. While these medications have transformed patient outcomes, they require careful management due to their potential side effects and limitations.
Antianxiety Medications
Antianxiety Medications
49