高脂蛋白的一致性 (a) 亲属之间的度
Laurens F Reeskamp1,2, Tycho R Tromp1, Aniruddh P Patel2,3,4
1Department of Vascular Medicine, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, the Netherlands.
JAMA cardiology
|October 11, 2023
概括
一级亲属的级联查在40%以上的病例中发现了高脂蛋白 (Lp[a]) 度. 这支持了对家庭成员进行查的建议,以确定有动脉样硬化心血管疾病 (ASCVD) 风险的个人.
科学领域:
- 心脏病学 心脏病学
- 遗传学 遗传学 是一个
- 公共卫生 公共卫生
背景情况:
- 脂蛋白 (Lp) 是动脉样硬化心血管疾病 (ASCVD) 的遗传性风险因素.
- 目前的指导方针建议对高Lp(a) 个体的亲属进行查,但人口水平的产量数据有限.
研究的目的:
- 确定高Lp (a) 度在高Lp (a) 个体的第一和二度亲属中的患病率.
- 为了将这种患病率与非相关个体的患病率进行比较.
主要方法:
- 英国生物库数据的横截面分析,比较第一级 (n=19,899) 和第二级 (n=9,715) 具有高Lp(a) 的亲属与非相关对 (n=184,764) 的Lp(a) 水平.
- 高Lp (a) 定义为≥125nmol/L.
主要成果:
- 一级亲属 (斯皮尔曼 ρ=0.45) 和二级亲属 (斯皮尔曼 ρ=0.22) 之间存在显著的相关性.
- 索引病例的一级亲属中有47.0%和二级亲属中有31.8%的Lp (a) 值高,而非亲属的Lp (a) 值高16.4%.
- 一级亲属患高Lp的几率是7.4倍,二级亲属患高Lp的几率是3.0倍,如果他们的指数亲属患高Lp的话.
结论:
- 对一级亲属的级联查显示,超过40%的个体的Lp (a) 水平很高.
- 这些发现验证了目前对家族Lp查的建议,以识别增加ASCVD风险的个体.
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