CO2 - - 驱动pH敏感的超分子聚合物的雾化,用于腹膜内凝形成和腹膜转移的治疗
Helena Braet1,2, Peter-Paul Fransen3, Remco Mariën1
1Department of Pharmaceutics, Ghent University, Ghent 9000, Belgium.
ACS applied materials & interfaces
|October 11, 2023
概括
这项研究引入了一种用于卵巢癌腹膜转移治疗的新型水凝. 可切换pH的水凝能够持续释放药物,延迟瘤的进展并改善存活率.
科学领域:
- 在瘤学瘤学.
- 纳米技术 纳米技术
- 生物材料是一种生物材料.
背景情况:
- 卵巢癌引起的腹转移 (PM) 往往表现为非特异性症状,导致晚期诊断.
- 目前腹腔内 (IP) 化疗的疗效受到IP腔中的快速药物清除的限制,通常使用非标签的静脉注射溶液.
- 压缩性腹腔内喷雾剂化疗 (PIPAC) 对无法切除的PM有希望,但需要优化药物输送系统.
研究的目的:
- 开发和评估一个装有纳米粒子的,pH值可切换的超分子聚合物水凝,用于控制PM中的药物输送.
- 评估位凝和水凝在腹腔内长时间保留的情况.
- 在临床前模型中研究新型水凝系统的持续药物释放和抗瘤疗效.
主要方法:
- 开发一个可切换pH的超分子聚合物水凝,装载有paclitaxel纳米晶体.
- 设计一个多向喷嘴,用于雾化粘性水凝,以使IP沉积均.
- 评估二氧化碳诱导的酸化引发的现场凝.
- 在体外评估药物释放动力学和细胞毒性.
- 在异种移植模型中进行腹膜转移的临床前评估.
主要成果:
- 水凝溶液在酸化后经过现场凝,延长了IP保留时间.
- 在体外研究表明,帕克利塔塞尔纳米晶体从水凝中持续释放10天.
- 在PM异种移植模型中,空气化水凝治疗显著延迟了瘤的进展.
- 与对照组相比,治疗组的总生存时间显著增加.
结论:
- 可切换pH的超分子聚合物水凝是一种可行的平台,用于控制卵巢癌PM中的IP药物输送.
- 开发的水凝系统增强了药物保留和持续释放,从而提高了抗瘤功效.
- 这种新的方法有可能改善无法切除的腹转移患者的治疗结果.
关键词:
皮帕克 (PIPAC) 是一个国际组织.在 ePIPAC 里面,你会发现纳米药物是一种纳米药物.喷嘴喷嘴是一个喷嘴.腹内转移的发生.可喷的凝喷雾剂这是一种超分子凝.持续释放 持续释放 持续释放更多相关视频
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