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在AMD眼睛中使用抗VEGF疗法后的冠状腺变化,具有不同类型的黄斑新血管化,使用扫描源OCT血管学

Mengxi Shen¹, Hao Zhou², Jie Lu²

¹Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida, United States.

Investigative ophthalmology & visual science

|October 11, 2023

概括

冠状腺厚度和血管度随着排泄性与年龄相关的黄斑变性 (AMD) 发病而增加,并在抗VEGF治疗后减少. 这些变化发生不论黄斑新血管化 (MNV) 的起源.

科学领域:

眼科医生眼科眼科
医疗成像医学成像
血管生物学血管生物学

背景情况:

排泄性与年龄相关的黄斑变性 (AMD) 涉及异常的血管生长.
斑点新血管化 (MNV) 可以起源于胆膜 (类型1/2) 或视网膜 (类型3).
了解AMD中的胆道变化对于治疗策略至关重要.

研究的目的:

在排泄性AMD中,在抗VEGF治疗之前和之后调查胆道变化.
为了比较源自胆膜和视网膜的MNV之间的这些变化.

主要方法:

扫描源光学连贯性断层扫描血管学 (SS-OCTA) 用于以前没有接受过治疗的AMD患者.
胸膜厚度和胸膜血管度指数 (CVI) 测量在以膜为中心的圆圈中.
测量是在排泄开始之前,在排泄开始期间和在抗VEGF治疗后进行的.

主要成果:

胸膜厚度和CVI从预处理到排泄开始时增加 (P ≤0.03).
在抗VEGF治疗后,胸膜厚度和CVI显著下降 (P < 0.001).
在1/2型MNV和3型MNV之间没有发现胆道变化的显著差异.

结论:

在AMD中,胸膜厚度和血管性随着排泄和抗VEGF治疗而波动.
这些胆道变化似乎是对益血管原生环境和随后的治疗的反应.
MNV的起源 (胸腔与视网膜) 并没有显著改变这些观察到的胸腔动态.

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