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马林克罗德特加工工人的第三次死亡后续调查,1942-2019年

Cato M Milder^1,2, Sara C Howard³, Elizabeth D Ellis³

¹Division of Epidemiology, Vanderbilt University Medical Center, Nashville, TN, USA.

International journal of radiation biology

|October 11, 2023

概括

这项对加工工人的研究发现大脑癌症的增加,并维持了辐射和癌,粉和病之间的联系. 心血管疾病的风险也随着辐射暴露而增加.

科学领域:

职业健康职业健康职业健康
辐射流行病学辐射流行病学
毒理学毒理学毒理学

背景情况:

马林克罗德化学工厂从1942年至1966年加工了.
工人面临着暴露于电离辐射和粉尘的危险.
这项研究是对2514名男性员工的癌症和非癌症死亡率的第三次随访.

研究的目的:

更新加工工人癌症和非癌症死亡率的研究结果.
评估与辐射和粉暴露的潜在关联.
分析与估计的个体器官剂量相关的健康结果.

主要方法:

估计的个体器官剂量从章,X射线,尿液分析和测量.
通过2019年评估了粉暴露和生命状况.
使用标准化死亡率,考克斯比例危险和波松回归模型.

主要成果:

观察到过多的脑癌死亡 (SMR:1.79),没有检测到辐射剂量反应.
辐射暴露和癌之间的持续联系 (HR在100mGy:2.07).
与心脏剂量 (HR 100 mGy: 1.11) 和与非恶性病相关的粉暴露增加了心血管疾病风险.

结论:

加强了先前关于多余脑癌的发现,并维持了对癌和粉相关脏疾病的关联.
观察到对心血管疾病的积极剂量反应,可能与吸烟有关.
未来的研究将将数据与其他加工工人队伍汇集在一起.

关键词:

辐射辐射辐射辐射辐射辐射辐射流行病学流行病学职业风险职业风险职业风险是一种.加工工人的工作人员.

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