通过饮用水长期暴露于酸盐对肠道屏障的影响
Adrián Domene1, Helena Orozco1, Pilar Rodríguez-Viso1
1Instituto de Agroquímica y Tecnología de Alimentos, Calle Agustín Escardino 7, 46980 Paterna, Spain.
Chemical research in toxicology
|October 11, 2023
概括
在饮用水中长期暴露于无机 (V) (AsV) 会损害肠道屏障. 这项研究表明,As(V) 导致氧化应激,炎症和肠道失调,导致肠道透性增加和内毒性.
科学领域:
- 环境健康 环境健康
- 毒理学 毒理学 毒理学
- 胃肠病学 胃肠病学
背景情况:
- 长期无机 (As) 暴露影响了数百万人,增加了癌症和非癌症病理.
- 口服是主要的暴露途径,但对肠道毒性的体内研究,特别是对AsV,是有限的.
- 现有的研究往往侧重于 (III) 毒性,在了解 (V) 对肠道的影响方面存在差距.
研究的目的:
- 为了研究慢性As(V) 暴露对BALB/c小鼠肠道屏障的影响.
- 确定有助于As(V) 诱导的肠道毒性的潜在机制.
- 为了评估在As(V) 暴露后肠道微生物群和新陈代谢的变化.
主要方法:
- BALB/c小鼠通过饮用水长期暴露在As(V) (15-60 mg/L) 中,持续6个月.
- 对肠道组织进行了氧化应激标记 (脂质过氧化,反应性物种) 和炎症 (细胞因子,中性粒细胞) 的分析.
- 评估了细胞间接口蛋白 (Claudins,Occludin) 和粘素 (Muc2) 的表达,肠道微生物群的组成,短链脂肪酸代谢,以及血清内毒性血清标志物.
主要成果:
- 由于V) 暴露引起了肠道组织中显著的氧化应激和炎症.
- 观察到细胞间连接处和粘液层中关键蛋白质的表达发生变化.
- 检测到肠道微生物群组成和短链脂肪酸概况的变化,以及细胞透性增加和内毒性病的迹象.
结论:
- 长期暴露于As(V) 会通过氧化应激,炎症和肠道失调破坏肠道屏障.
- 这些干扰有助于增加肠道透性和全身内毒性.
- 这些发现凸显了As(V对肠道环境和宿主健康的有害影响.
相关概念视频
Barrett Esophagus-I: Introduction
105
Barrett's esophagus is a medical condition where the esophageal mucosa is significantly damaged by stomach acid or other digestive fluids, often due to long-term exposure associated with gastroesophageal reflux disease (GERD). In GERD, a weakened or abnormally relaxed lower esophageal sphincter allows stomach acid to flow persistently into the esophagus.
This constant acid exposure transforms the esophagus's pink mucosal lining (stratified squamous epithelium) into a type of lining more...
This constant acid exposure transforms the esophagus's pink mucosal lining (stratified squamous epithelium) into a type of lining more...
105
Toxic Reactions: Overview
992
When toxic substances penetrate the human body, they disseminate to various tissues, undergoing metabolic changes. This process yields reactive metabolites that may covalently bind with specific target molecules, resulting in toxicity.
Toxicity falls into two primary categories: local and systemic.
Local toxicity appears at the exposure site, such as protein denaturation caused by caustic substances.
In contrast, systemic toxicity requires the toxic agent's absorption and distribution,...
Toxicity falls into two primary categories: local and systemic.
Local toxicity appears at the exposure site, such as protein denaturation caused by caustic substances.
In contrast, systemic toxicity requires the toxic agent's absorption and distribution,...
992
Types of Toxins
1.7K
Humans continually engage with an environment rich in potentially harmful chemicals. These are introduced to our bodies through inhalation, ingestion, or skin contact. These chemicals exist in various forms, such as air and environmental pollutants, agricultural chemicals, organic solvents, and heavy metals.
Air pollutants, primarily gases, pose significant threats to respiratory health, leading to conditions like hypoxia, lung cancer, and in extreme cases, death.
Environmental pollutants like...
Air pollutants, primarily gases, pose significant threats to respiratory health, leading to conditions like hypoxia, lung cancer, and in extreme cases, death.
Environmental pollutants like...
1.7K
Factors Influencing Drug Absorption: Disease States and Pharmacology
538
Multiple disease states can significantly influence the oral drug absorption process by affecting blood flow and the functionality of the gastrointestinal (GI) system. Various GI diseases, including conditions that alter GI motility, such as diarrhea, decreased acid secretions (achlorhydria), and infections, have been associated with reduced drug absorption.
Substances such as alcohol and specific drugs, including antineoplastics, can also negatively impact drug absorption. For instance,...
Substances such as alcohol and specific drugs, including antineoplastics, can also negatively impact drug absorption. For instance,...
538
Prevention of Further Absorption of Poison
835
In cases of acute poisoning, the primary objective is to prevent further absorption of the toxic substance into the body. Immediate interventions using various decontamination techniques targeting the gastrointestinal (GI) tract can achieve this. Decontamination is crucial to prevent poison from entering the systemic circulation, which involves washing affected areas with water and mild soap and removing contaminated clothing. Once external decontamination is done, attention must be turned to...
835
Drugs Affecting GI Tract Motility: Adsorbents as Antidiarrheal Agents
224
Diarrhea is characterized by the occurrence of frequent, watery bowel movements. Various factors can trigger diarrhea, including viral or bacterial infections, foodborne illnesses, side effects from certain medications, and underlying digestive disorders. If not adequately managed, diarrhea can lead to complications such as dehydration, electrolyte imbalances, and nutrient deficiencies. Severe diarrhea can lead to significant weight loss, malnutrition, and weakened immune function.
Adsorbents...
Adsorbents...
224


