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胃绕道术后食用低血糖的达西格卢卡贡治疗:一个随机,双盲,安慰剂控制的试验
Casper K Nielsen1,2, Caroline C Øhrstrøm3, Inas J K Houji1
1Center for Clinical Metabolic Research, Copenhagen University Hospital-Herlev and Gentofte, Hellerup, Denmark.
Diabetes care
|October 11, 2023
概括
在一项试验中,达西格卢卡贡有效地治疗了腹痛后低血糖症,在Roux-en-Y胃绕道手术后显著降低了低血糖事件. 这种稳定的葡萄糖类比为管理这种常见并发症提供了一个有前途的新选择.
科学领域:
- 代谢手术 代谢手术
- 内分泌学 在内分泌学.
- 药理学 药理学是指药理学的学科.
背景情况:
- 腹腔后低血糖症是一种常见的并发症,在Roux-en-Y胃旁路术 (RYGB) 后影响超过50%的患者.
- 目前这种疾病的治疗方法有限,往往缺乏效率.
- 达西格卢卡贡是一种稳定,准备使用的葡萄糖类相应物,已经显示出缓解低血糖的潜力.
研究的目的:
- 为了评估达西格卢卡贡在降低腹痛后低血糖症方面的疗效.
- 评估在门诊环境中自给定西格卢卡贡的低血糖阻碍潜力.
主要方法:
- 一项随机,双盲,安慰剂控制的交叉研究与24名经验证低血糖症的RYGB患者进行.
- 参与者在4周内接受了自给自取的皮下达西格卢卡贡 (120微克) 或安慰剂.
- 主要和次要结局测量了使用连续血糖监测在不同水平的低血糖症中花费的时间的百分比.
主要成果:
- 与安慰剂相比,达西葡萄糖显著减少了1级低血糖症的时间,减少了33% (P = 0.002) 和2级低血糖症的时间,减少了54% (P < 0.0001).
- 低血糖在15分钟内纠正了97.3%的达西格卢卡贡给药人,而安慰剂为29.1% (P<0.001).
- 达西格卢卡贡耐受性良好,轻度至中度的恶心是主要的不良事件.
结论:
- 自给药的达西格卢卡贡在RYGB后的个体中有效减少了临床相关的低血糖症.
- 达西葡萄糖代表了一种可行的治疗选择,用于管理腹痛后低血糖症.
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