在海地实施基于医院的状细胞新生儿查和随访计划
Ofelia A Alvarez1, Nora St Victor Dély2, Michele Paul Hanna3
1Division of Pediatric Hematology, University of Miami, Miami, FL.
Blood advances
|October 11, 2023
概括
新生儿查状细胞病 (SCD) 和随访计划在海地是可行的. 临床检测显著提高了随访率,尽管跨皮多普勒查存在挑战.
科学领域:
- 全球健康 全球健康
- 儿科 儿科 儿科
- 遗传学 是一个遗传学.
背景情况:
- 状细胞病 (SCD) 影响了海地每120名儿童中就有1名儿童.
- 医疗保健面临的挑战包括有限的新生儿查 (NBS) 和缺乏跨的多普勒 (TCD) 超声波来评估中风风险.
研究的目的:
- 评估在海地实施基于医院的NBS和SCD的后续计划的可行性.
- 评估传统的NBS与照顾点 (POC) 测试在改善随访率方面的有效性.
主要方法:
- 使用传统的干血点检测和POC检测的NBS在海地四个地点实施.
- 在方法之间比较了SCD确定的新生儿的临床随访率.
- 165名患有SCD的参与者被招募用于随访,并接受了青素.
主要成果:
- 在8224名接受查的新生儿中,SCD在0.77%的新生儿中被发现.
- 在农村环境中进行点照顾测试的结果是56%的随访率,而没有POC的随访率为0% (P = .044).
- TCD查面临着重大实施挑战,包括互联网和员工保留能力不佳.
结论:
- 在海地实施NBS和SCD计划是可行的,特别是通过POC测试.
- 需要策略来缓解实施挑战,例如TCD限制.
- 成功的招募和治疗启动证明了海地改善SCD护理的潜力.
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