儿科使用耐甲基西林黄金葡萄球菌鼻膜片用于抗菌管理
Shienna Braga1, Nipunie Rajapakse2, Jamie Heyliger1
1From the Department of Pharmacy, Mayo Clinic, Rochester, Minnesota.
The Pediatric infectious disease journal
|October 11, 2023
概括
甲素耐药黄金葡萄球菌 (MRSA) 鼻 (MNS) 在儿童中显示出高负预测值 (NPV),这表明它们可以帮助安全地减少抗生素使用. 负的MNS结果可以指导儿童患者的MRSA治疗减缓.
科学领域:
- 儿童传染病 儿童传染病
- 抗微生物药物管理委员会
- 临床微生物学 临床微生物学
背景情况:
- 耐甲基西林黄金葡萄球菌 (MRSA) 引起了严重的儿科感染,往往需要经验性抗MRSA抗生素治疗.
- 成人研究表明,MRSA鼻 (MNS) 具有高负预测值 (NPV),有助于抗生素降级.
- 对于指导抗MRSA治疗的儿科人群中MNS实用性的数据有限.
研究的目的:
- 在怀疑感染的住院儿童中评估MNS的NPV和积极预测值 (PPV).
- 评估MNS在指导儿童患者MRSA感染的抗微生物管理中的作用.
主要方法:
- 在单个地点进行的回顾性队列研究.
- 包括2018年6月1日至2022年11月25日期间住院的儿科患者,怀疑感染诊断和进行MNS.
- 分析MNS结果与来自感染源的微生物培养相比.
主要成果:
- 这项研究包括172名儿科患者.
- 在6.4%的MNS和5.8%的感染部位培养物中检测到MRSA.
- 对于所有感染部位,MNS的敏感度为20%,特异性为94%,PPV为18%,NPV为95%.
结论:
- 在儿科患者中,MRSA鼻子拭子显示高的NPV和低的PPV.
- 在儿童中,MNS可以作为一种有价值的抗微生物管理工具,用于降低抗MRSA抗生素的升级.
- 这些发现支持使用MNS来优化小儿MRSA管理中的抗生素治疗.
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