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Updated: Jul 13, 2025

Human Liver Microphysiological System for Assessing Drug-Induced Liver Toxicity In Vitro
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一种权方法来整合大奥米克和机械评估DILI

Yuan Jin1,2, Yingqing Shou2, Qinkai Lei2

  • 1Key Laboratory of Birth Regulation and Control Technology of National Health Commission of China, Maternal and Child Health Care Hospital of Shandong Province Affiliated to Qingdao University, Jinan, China.

Hepatology (Baltimore, Md.)
|October 11, 2023
PubMed
概括

这项研究开发了一种新的机器学习方法,通过整合各种数据集和分析毒性途径来预测药物诱导的肝损伤 (DILI). 该模型实现了超过86%的精度,有助于药物开发和患者安全.

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相关概念视频

Mechanistic Models: Compartment Models in Individual and Population Analysis01:23

Mechanistic Models: Compartment Models in Individual and Population Analysis

Mechanistic models are utilized in individual analysis using single-source data, but imperfections arise due to data collection errors, preventing perfect prediction of observed data. The mathematical equation involves known values (Xi), observed concentrations (Ci), measurement errors (εi), model parameters (ϕj), and the related function (ƒi) for i number of values. Different least-squares metrics quantify differences between predicted and observed values. The ordinary least...
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