带有p-酸的纳米脂质体:优化,表征,抗菌性质和对新鲜豆果的保存效应
Peiye Liu1, Jing Shen2, Jiankang Cao3
1College of Food Science and Nutritional Engineering, China Agricultural University, Beijing 100083, China; China Household Electric Appliance Research Institute, Beijing 100037, China.
Food chemistry
|October 11, 2023
概括
新型纳米脂质体有效封装p-coumaric acid (pCA),增强其用于食品保存的抗菌性质. 这些载有pCA的纳米脂质体通过抑制真菌生长和减少腐烂来延长新鲜胡的保质期.
科学领域:
- 食品科学与技术 食品科学与技术
- 纳米技术纳米技术
- 农业科学 农业科学
背景情况:
- 酸 (pCA) 具有与食品保存相关的抗菌性质.
- 提高pCA的稳定性和有效性对于其实际应用至关重要.
- 纳米脂质体为生物活性化合物提供了一个有前途的输送系统.
研究的目的:
- 开发和描述用于食品保存的p-酸 (pCA) 装载纳米脂质体.
- 评估pCA载纳米脂质体对新鲜产品的抗菌活性和延长保质期的影响.
主要方法:
- 使用薄膜水化和超声波处理制备带有pCA的纳米脂质体.
- 通过响应表面方法来优化纳米脂质体配方.
- 纳米脂质体的特征 (大小,分散性,封装效率) 和稳定性评估.
- 在体外化实验中评估对Botrytis cinerea的抑制作用.
- 对新鲜的保质期延长的评估.
主要成果:
- 制造的pCA装载纳米脂质体是纳米尺寸的球状囊泡 (83.55 ± 0.34 nm),具有良好的分散性和封装效率 (55.70 ± 0.10%).
- 福利埃变换红外光谱学证实了通过疏水性相互作用和键的pCA封装.
- 纳米脂质体表现出增强的温度和离心稳定性,减少聚合.
- 装有pCA的纳米脂质体有效地抑制了Botrytis cinerea在胡上的扩张,并通过减少体重减轻和腐烂,延长了保质期.
结论:
- 脂质体封装是一种可行的策略,可以增强pCA的抗菌活性.
- 载有pCA的纳米脂质体显示出改善食品保存和延长新鲜农产品的保质期的巨大潜力.
- 这种方法提供了一种有效的方法,用于在食品应用中提供生物活性化合物.
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