生物物理的洞察力蛋白质-蛋白质相互作用在互联联氨基素-11/互联氨基素-11Rα/糖蛋白130信号复合体

Chinatsu Mori1, Satoru Nagatoishi2, Ryo Matsunaga3

  • 1Department of Chemistry and Biotechnology, School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8656, Japan.

概括

互乐金-11 (IL-11) 信号传递在热力学上不同于互乐金-6 (IL-6). 独特的IL-11复杂相互作用与糖蛋白130 (gp130) 解释了其在炎症和癌症中的独特生物学作用.

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