多基因胚胎查:有潜在的孕产妇和胎儿危害吗?
Perrine Ginod1, Michael H Dahan2
1MUHC Reproductive Centre, McGill University, Montréal, Quebec, Canada; CHU Dijon Bourgogne, Service de Gynécologie-Obstétrique et Assistance Médicale à la Procréation, Dijon, France.
Reproductive biomedicine online
|October 11, 2023
概括
多基因胚胎查 (PES) 和胚胎健康评分 (EHS) 旨在改善后代的健康,但带有不确定的风险. 进一步的研究对于对潜在的危害与益处进行知情的患者咨询至关重要.
科学领域:
- 生殖医学 生殖医学
- 遗传学 遗传学 是一个
- 胚胎学 胚胎学
背景情况:
- 多基因胚胎查 (PES) 和胚胎健康评分 (EHS) 是胚胎选择的新兴技术.
- 有关潜在的IVF危害存在担忧,包括未被EHS捕获的表观遗传变化.
- 皮活检是PES的组成部分,可能会对后代的健康构成风险.
研究的目的:
- 审查 PES 和 EHS 的潜在风险和好处.
- 突出有关 PES 影响的当前知识中的不确定性.
- 强调患者知情决策的重要性.
主要方法:
- 关于多基因胚胎查的文献综述.
- 分析了对皮活检结果的研究.
- 综合有关IVF相关表观遗传变化和后代健康的数据.
主要成果:
- PES/EHS显示出选择更健康的胚胎的潜力.
- 皮活检与潜在的风险增加有关,如早产和子宫前.
- 从IVF/PES的长期健康影响和表观遗传变化仍然在很大程度上未得到量化.
结论:
- 与PES相关的产前和产后健康风险尚未完全理解.
- 进一步的研究是必要的,以澄清PES的安全性和有效性.
- 针对 PES 程序的知情同意,全面的患者咨询至关重要.
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