在辅助生殖技术后,单产儿头周长的性别特异性差异:日本的一项多中心研究
Seiko Matsuo1, Takafumi Ushida2, Sho Tano1
1Department of Obstetrics and Gynecology, Nagoya University Graduate School of Medicine, Showa-ku, Nagoya, Japan.
Reproductive biomedicine online
|October 11, 2023
概括
辅助生殖技术 (ART) 增加了新生儿,特别是男性头部周长大大的风险. 特定的ART方法,如冷胚胎移植与这一结果有关.
科学领域:
- 新生儿健康 新生儿健康
- 生殖医学 生殖医学
- 儿科生长的成长 儿科的成长
背景情况:
- 辅助生殖技术 (ART) 被广泛用于不孕症.
- 对ART对新生儿人体测量的潜在影响需要进行调查.
- 头周长是新生儿发育的一个关键指标.
研究的目的:
- 为了研究辅助生殖技术 (ART) 和头周长在期独生子之间的关联.
- 为了比较ART,非ART生育治疗和自然受孕之间的风险.
- 探索特定ART手术对新生儿头部周长的影响.
主要方法:
- 分析了来自12家日本产科医院的32,651例单期分娩 (2010-2018).
- 怀孕方法的分类:ART,非ART生育治疗和自然怀孕.
- 对头周长≥90百分位的调整几率比率的评估,按婴儿性别和ART类型分层.
主要成果:
- ART显著增加了头周长≥90百分位 (aOR 1.56) 的风险.
- 非ART的生育治疗没有显示出显著的风险增加 (aOR 1.14).
- 增加的风险仅在男性新生儿 (aOR 1.73) 中观察到,并且与冷胚胎移植 (FET),激素替代周期 FET (HRC-FET) 和胚芽细胞阶段胚胎移植有关.
结论:
- 与自然受孕或非ART治疗相比,使用ART,特别是特殊手术,与新生儿头部周长较大的风险有关.
- 这种关联主要在男婴中观察到.
- 研究结果强调需要进一步研究ART对胎儿发育和新生儿后果的影响.
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