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在语义性痴呆症中,基线自主流出减少与左侧化胰岛缩有关

Alice Y Hua¹, Ashlin R K Roy¹, Eena L Kosik¹

¹Department of Neurology, University of California, San Francisco, Memory and Aging Center, San Francisco, CA, USA.

NeuroImage. Clinical

|October 11, 2023

概括

语义性痴呆症 (SD) 患者表现出自主神经系统活动减少,与左侧大脑缩有关. 这影响了语义性痴呆症变体中的社会行为,特别是外向.

科学领域:

神经科学是一个神经科学.
自主神经系统生理学自主神经系统生理学
认知神经学认知神经学

背景情况:

语义性痴呆症 (SD) 涉及前叶的不对称变性,导致语义知识丧失和社会情感变化.
两个SD变体,svPPA (左侧缩) 和sbvFTD (右侧缩),影响不同的大脑区域.
以前的研究将前性痴呆与自主神经系统活动受损和社会情绪缺陷联系在一起.

研究的目的:

在语义性痴呆症 (SD) 中调查休息自主神经系统活动.
为了确定SD中自主性障碍是否与左侧脑缩相关.
检查自主功能,大脑缩和SD中减少的附属行为之间的关系.

主要方法:

在33名SD患者 (20svPPA,13sbvFTD) 和49名对照患者中评估了呼吸道鼻律不整 (RSA; 副交感) 和皮肤导电水平 (SCL; 交感).
利用结构磁共振成像用于基于voxel的形态测量来分析大脑缩模式.
采集了使用人际形容词尺度对关联行为的告密者评分.

主要成果:

与健康对照组相比,SD患者的基线RSA和SCL显著较低.
基于voxel的形态测量显示SD的左侧缩大于右侧缩,与减少的副交感和交感外流相关.
左侧化胰岛缩与较低的RSA (中后胰岛) 和SCL (腹前胰岛) 相相关;较低的RSA与SD中的外向性减少有关.

结论:

语义性痴呆与自主神经系统调节受损有关,反映了左侧脑缩.
自主功能障碍,特别是降低的副交感活动,与SD中外向性减少有关.
这项研究扩大了对svPPA和sbvFTD社会情绪变化的生物学基础的理解.

关键词:

自主神经系统的自主神经系统.电皮活动电皮活动同理心同理心同情心心率变化心率的变化.语义性痴呆症是一种痴呆症.

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