戒烟改善了诊断非小细胞肺癌后的两年生存率
Rachel E Gemine1, Gareth R Davies2, Kirsty Lanyon3
1Department of Research & Development, Innovation & Value Based Health, Hywel Dda University Health Board, Prince Philip Hospital, Llanelli, Wales; Research & Innovation, Digital Health and Care Wales, Cardiff, Wales; School of Medicine, Faculty Health Sciences, Swansea University, Singleton Park, Swansea, Wales.
在肺癌诊断后戒烟显著提高了生存率. 戒烟的患者比继续吸烟的患者活得更长,这凸显了戒烟支持的重要性.
科学领域:
- 在瘤学瘤学.
- 肺部病理学 肺部病理学
- 成 药物 药物 药物 药物
背景情况:
- 在诊断时吸烟与较差的肺癌存活率有关.
- 戒烟对生存结果的影响尚不清楚.
研究的目的:
- 研究戒烟对非小细胞肺癌 (NSCLC) 患者存活率的影响.
主要方法:
- 在英国的一项多中心观察性研究中,对2751名新诊断的NSCLC患者进行了长达2年的随访.
- 吸烟状态被验证,并提供戒烟支持.
- 使用卡普兰-梅尔分析和考克斯比例危险建模来评估生存率.
主要成果:
- 戒烟者比继续戒烟者 (32%) 的2年生存率要好得多 (45%).
- 戒烟者的中位生存时间为659天,而继续戒烟的人为348天.
- 戒烟在调整临床因素后,将死亡风险降低了25%.
结论:
- 戒烟独立地与改善NSCLC患者的生存率有关,无论癌症的阶段如何.
- 为所有吸烟的肺癌患者推戒烟建议和治疗.
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