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释放车:CTLA-4损耗轮增压CAR-T电池

Roland C Schelker1, Luca Gattinoni2

  • 1Division of Functional Immune Cell Modulation, Leibniz Institute for Immunotherapy, Regensburg, Germany; Department of Internal Medicine III, University Hospital Regensburg, Regensburg, Germany.

Immunity
|October 11, 2023
PubMed
概括

通过CRISPR/Cas9删除CTLA4,可以恢复CAR-T细胞的适应性和抗瘤功能,克服免疫检查点引起的治疗失败. 这种方法增强了CD28信号传输,提高了CAR T细胞治疗的疗效.

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