癌细胞内在的机制驱动获得的免疫耐受性
Ehsan Ghorani1, Charles Swanton2, Sergio A Quezada3
1Cancer Immunology and Immunotherapy Unit, Department of Surgery and Cancer, Imperial College London, London, UK; Department of Medical Oncology, Imperial College London Hospitals, London, UK.
Immunity
|October 11, 2023
概括
癌细胞通过控制维持自我容忍的途径来逃避免疫破坏. 了解这些癌细胞内在因素是开发针对免疫逃避和改善患者分层的新疗法的关键.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 癌症生物学 癌症生物学
背景情况:
- 免疫逃避是一种关键的机制,使瘤能够抵抗宿主免疫反应.
- 癌细胞开发了内在的策略,以避免免疫识别和T细胞的破坏.
研究的目的:
- 审查癌细胞内在的驱动免疫逃避的因素.
- 基于对T细胞功能的控制来对免疫逃避机制进行分类.
主要方法:
- 文献综述侧重于癌细胞内在的免疫逃避机制.
- 框架开发,对与T细胞局部化,抗原识别和效应器功能相关的逃避策略进行分类.
主要成果:
- 癌细胞劫持自我耐受路径,以逃避免疫破坏.
- 逃避的机制包括控制T细胞局部化,抗原识别和效应器功能.
- 在癌症免疫逃避中存在显著的途径冗余.
结论:
- 针对癌细胞内在的免疫逃避,需要对这些多方面的机制有全面的了解.
- 需要开发更好的工具,以便在基于免疫逃避概况的临床试验中对患者进行分层.
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