暴露后大脑网络连接的变化和对青少年和成人强迫性障碍的反应预防疗法
Hannah C Becker1, Adriene M Beltz2, Joseph A Himle3
1Department of Psychology, University of Michigan, Ann Arbor, Michigan; Department of Psychiatry, University of Michigan, Ann Arbor, Michigan.
Biological psychiatry. Cognitive neuroscience and neuroimaging
|October 11, 2023
概括
暴露和响应预防 (EX/RP) 疗法改善了强迫症患者的前端对象网络 (FPN) 连接. 这些在青少年和成年人中观察到的变化表明EX/RP可能会恢复健康的大脑发育.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 认知科学 认知科学
背景情况:
- 强迫症 (OCD) 与关键大脑网络的功能连接性发生变化有关,包括前端对称网络 (FPN), cingulo-opercular网络和默认模式网络.
- 诸如暴露和反应预防 (EX/RP) 等黄金标准治疗对强迫症患者这些网络变化的影响仍然不清楚.
- 了解不同年龄组的治疗诱导网络调制对于确定敏感的治疗点至关重要.
研究的目的:
- 研究暴露和响应预防 (EX/RP) 对青少年和成年患有强迫症 (OCD) 患者功能性大脑网络连接的影响.
- 为了比较EX/RP与活性控制疗法 (压力管理培训) 对网络连接的影响.
- 为了确定与治疗相关的网络连接变化是否在青少年和成人强迫症患者之间有所不同.
主要方法:
- 功能性磁共振成像 (fMRI) 用于评估169名参与者 (58名健康对照,111名强迫症患者;青少年和成年人) 的侧边任务期间的大脑活动.
- 参与者被随机分配到EX/RP或压力管理培训中.
- 采用组代多重模型估计来分析前后处理前后处理前前后处理前前后处理前前后处理前前后处理前前前后处理前前前后处理前前前后处理前前前后处理前前后处理前前前后处理前前前后处理前前后处理前后处理前后处理前后处理前后处理前后处理前后处理前后处理前后处理前后处理前后处理前后处理前后处理前处理前处理前处理前处理前处理前处理前处理前处理前处理前处理后处理后处理后处理后处理前处理前处理前处理前处理前处理前处理前处理前处理前处理前处理前处理后处理后处理前处理前处理前处理前处理前处理前处理后处理前处理前处理前处理前处理前处理前处理前处理前处理前处理前处理前处理后处理后处理后处理后处理后处理后处理前处理前处理前处理前处理前处理前处理前处理前处理前处理前处理前处理后处理后处理后处理前处理前处理前处理前处理前处理前处理前处理后处理后处理后处理后处理
主要成果:
- 接受EX/RP治疗的患者从治疗前到治疗后显著增加了前对对面网络 (FPN) 密度,并减少了FPN-默认模式网络密度.
- 接受压力管理培训的患者表现出相反的网络密度变化模式.
- 这些与治疗相关的网络密度变化在青少年和成人年龄组一致.
结论:
- 暴露和响应预防 (EX/RP) 疗法在患有强迫症 (OCD) 患者的大脑网络中的基于任务的功能连接中引发了特定的变化.
- 这些发现表明,EX/RP可能有助于在强迫症患者中恢复典型的前端双关节网络 (FPN) 和默认模式网络发展.
- 观察到的与治疗相关的网络变化为改善治疗反应和改善不同年龄组的强迫症认知控制提供了潜在的目标.
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