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瘤细胞和与瘤相关的巨细胞之间的小细胞外囊泡介导的细胞相互作用:对免疫治疗的含义

Liaoran Niu¹, Qi Wang², Fan Feng³

¹Department of Digestive Surgery, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi, China; State Key Laboratory of Cancer Biology and National Clinical Research Center for Digestive Diseases, Xijing Hospital of Digestive Diseases, Fourth Military Medical University, Xi'an, Shaanxi, China.

Biochimica et biophysica acta. Molecular basis of disease

|October 11, 2023

概括

小型细胞外囊泡 (sEVs) 介导癌细胞和巨细胞之间的通信,影响瘤的进展. 本综述探讨了癌细胞衍生的和巨细胞衍生的sEVs如何影响巨细胞两极分化和瘤恶性病变,讨论了治疗潜力.

科学领域:

癌症生物学癌症生物学
蜂通信蜂通信
免疫学免疫学免疫学

背景情况:

瘤微环境涉及癌细胞和肌层细胞,特别是巨细胞之间的复杂相互作用.
巨细胞表现出可塑性,分化为促炎 (M1) 或抗炎 (M2) 现型,显著影响瘤进展.
小型细胞外囊泡 (sEVs) 是瘤微环境中的细胞间通信的关键媒介.

研究的目的:

综合审查癌细胞衍生的sEVs在调节巨细胞极化中的作用.
检查巨细胞分泌的sEVs对瘤恶性转化过程的影响.
讨论与癌症中的巨相关的sEVs相关的治疗策略和挑战.

主要方法:

文学综述综合了关于sEVs和巨细胞与癌细胞相互作用的当前研究.
分析SEV (miRNAs, lncRNAs,蛋白质,脂质) 中的分子载荷及其功能后果.
探索sEVs对瘤进展和治疗耐药性的关键方面的影响.

主要成果:

癌细胞衍生的sEVs可以诱导特定的巨细胞极化状态,影响瘤微环境.
巨细胞衍生的sEVs通过影响扩散,转移,血管生成,化学抵抗和免疫逃避来促进瘤的进展.
sEVs是一个双刃剑,有潜力促进和抑制瘤生长,这取决于它们的来源和货物.

结论:

sEVs是癌症巨细胞交叉通话中的关键参与者,推动瘤进展和治疗耐药性.
向巨细胞相关的sEVs为新型癌症疗法提供了一个有希望的途径.
需要进一步的研究来克服利用sEVs有效治疗癌症的挑战.

关键词:

免疫治疗是一种免疫疗法.巨细胞是什么?巨细胞是什么?瘤细胞是一种瘤细胞.瘤微环境是一个微环境.sEVs 的使用情况.

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