贝加莫特多糖类通过调节肠道微生物群和代谢物来缓解DSS诱导的性结肠炎
Yiren Yang1, Yuwei Zhang1, Jiangping Song2
1Chaozhou Branch of Chemistry and Chemical Engineering Guangdong Laboratory, Chaozhou 521031, China; School of Light Industry and Food Engineering, Guangxi University, Nanning 530004, China.
International journal of biological macromolecules
|October 11, 2023
概括
贝加莫特多糖 (BP) 通过促进有益的肠道细菌和增加有益的代谢物来缓解结肠炎. 这调节肠道微生物群和新陈代谢,减少炎症和改善肠道屏障功能.
科学领域:
- 胃肠病学 胃肠病学
- 微生物学 微生物学
- 生物化学 生物化学
背景情况:
- 炎症性肠道疾病,如大肠炎,对健康构成重大挑战.
- 探索饮食干预措施来管理大肠炎.
- 贝加莫特多糖 (BP) 是一种具有潜在治疗功能的植物性化合物.
研究的目的:
- 在小鼠模型中研究柏格莫特多糖 (BP) 对改善硫酸 (DSS) 诱导的大肠炎的疗效.
- 阐明潜在的机制,包括对肠道微生物群,新陈代谢和肠道屏障功能的影响.
主要方法:
- 在小鼠中使用硫酸德克斯 (DSS) 诱导的大肠炎模型.
- 贝加莫特多糖化合物 (BP) 组成和分子量的特征.
- 肠道微生物群分析 (16S rRNA测序).
- 代谢学分析 (LC-MS).
- 评估炎症标记物和肠道屏障蛋白 (紧结蛋白,粘蛋白).
主要成果:
- 柏格莫特多糖 (BP) 显著缓解了DSS诱导的大肠炎症状,包括体重减轻和结肠缩短.
- 高血压治疗调节了肠道微生物群,促进了有益细菌的生长,如Bifidobacteria,Butyrivibrio和Blautia.
- 高血压增加了短链脂肪酸 (SCFA) 和L-氨的水平,与改善的氨,氨酸和氨酸代谢有关.
- 经过验证,L-氨具有抗炎活性.
- 血压增强了紧密结合蛋白和粘素的表达,表明肠道屏障完整性得到改善.
结论:
- 贝加莫特多糖 (BP) 显示出治疗大肠炎的治疗潜力.
- 高血压通过调节肠道微生物群组成和代谢概况来发挥其有益作用.
- BP的抗炎作用与SCFA产量增加和L-氨水平增加有关,导致肠道屏障功能增强.
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