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对抗Mycobacterium疹感染的替代疗法

Ivana Palucci¹, Giovanni Delogu²

¹Dipartimento di Scienze di Laboratorio e Infettivologiche, Fondazione Policlinico Universitario "A. Gemelli" IRCCS, Rome, Italy; Dipartimento di Scienze Biotecnologiche di Base, Cliniche Intensivologiche e Perioperatorie - Sezione di Microbiologia, Università Cattolica del Sacro Cuore, Rome, Italy.

Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases

|October 11, 2023

概括

替代疗法为治疗 Mycobacterium abscessus (Mab) 感染,解决耐药性和改善患者治疗结果提供了新的希望. 研究探索了超越标准抗生素尾酒的新策略,以获得更好的疗效.

科学领域:

传染性疾病传染性疾病
微生物学微生物学
药物发现药物发现药物发现

背景情况:

菌 (Mycobacterium abscessus,Mab) 是一种高致病性,快速生长的菌,可引起严重的肺和肺外感染,特别是在囊性纤维化患者中.
马布表现出显著的内在和获得的耐药性,限制了治疗选择,并导致标准,漫长和有毒药物治疗方案的预后不佳.
目前的标准治疗方法,通常是化物和阿米卡辛的组合,具有低于最佳的疗效和高毒性,需要创新的治疗方法.

研究的目的:

这篇叙事综述总结了最近关于Mycobacterium疹感染的替代治疗策略的研究.
它强调了对适当的实验分析的关键需求,以评估这些新型治疗的活性.

主要方法:

使用PubMed和MEDLINE数据库进行了全面的文献搜索,截至2023年6月.
搜索术语包括"Mycobacterium abscessus"",抗微生物药物"和"替代疗法".
从主要搜索结果中确定了额外的相关引用.

主要成果:

该审查涵盖了多种不同的替代疗法,包括宿主导疗法,重定向药物,菌体疗法,抗病毒策略,精油和吸入疗法.
这些新兴策略旨在克服对Mab感染常规治疗的局限性.

结论:

替代疗法作为一种有价值的策略,在由Mycobacterium abscessus引起的疾病中对抗抗菌素耐药性具有显著的希望.
开发和验证这些新的方法对于改善治疗结果和有效管理Mab感染至关重要.

关键词:

替代疗法替代疗法创新的方法创新的方法.这种细菌是Mycobacterium abscessus.非结核性菌根杆菌是没有结核的.

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