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大型抑郁症患者的冠状血管密度使用扫描源光学连贯性断层扫描血管学

Yan Wang¹, Lei Liu², Cong Li¹

¹School of Medicine, South China University of Technology, Guangzhou, China; Guangdong Eye Institute, Department of Ophthalmology, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, China.

Journal of affective disorders

|October 11, 2023

概括

重度抑郁症 (MDD) 与胆道血管密度 (VD) 的降低有关,这表明胆道血管的潜在血管变化. 这一发现表明MDD与视网膜血液供应受损之间存在联系.

科学领域:

眼科医生眼科眼科
神经科学是一个神经科学.
血管生物学血管生物学

背景情况:

以前的研究表明,大抑郁症 (MDD) 中的视网膜结构损伤.
肌,对于视网膜的营养至关重要,容易受到系统性变化的影响.
MDD对冠状腺结构的影响在很大程度上仍未被探索.

研究的目的:

在被诊断患有MDD的患者中调查胸腔血管密度 (VD).
使用扫描源光学连贯断层扫描血管学 (SS-OCTA) 进行精确的静脉动脉测量.
探索MDD和胆道血管改变之间的潜在相关性.

主要方法:

在MDD患者和健康对照者 (HCs) 中使用SS-OCTA评估冠状腺和视网膜VD.
使用诊断和国际疾病分类,第10版 (ICD-10) 标准确认了MDD诊断.
自动计算VD作为船舶面积与地区总面积的比率.

主要成果:

与HC相比,MDD患者表现出明显较低的上鼻和冠状血管体积 (CVV),冠状血管体积指数 (CVI) 和上鼻和冠状血管体积体积 (CSV) (p <0.05).
经过调整后的分析显示,缩短时间CVV和MDD之间存在显著的关联 (β = -9.31,p = 0.040).
两组之间没有观察到冠状腺厚度或视网膜VD的显著差异 (p > 0.05).

结论:

胆道血管密度下降与严重抑郁症相关.
研究结果表明,MDD患者的冠状腺血管功能障碍可能存在.
需要进一步的纵向研究来了解这些血管变化的进展.

关键词:

冠状血管密度冠状血管密度大型抑郁症主要是抑郁症.光学连贯断层扫描扫描血管图谱.

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