2014年至2022年使用葡萄糖类1受体激动剂的趋势
Journal of the American Pharmacists Association : JAPhA
|October 11, 2023
概括
葡萄糖类1 (GLP-1) 受体激动剂的使用迅速增加,特别是Ozempic,Wegovy和Mounjaro. 这项研究分析了现实世界的数据,突出了减肥和相关疾病处方模式的重大转变.
科学领域:
- 药理学和治疗学 药理学和治疗学
- 内分泌学和新陈代谢学
- 现实世界的证据研究研究.
背景情况:
- 最近FDA批准了用于减肥的葡萄糖类1 (GLP-1) 受体激动剂,这激起了对需求的兴趣.
- 缺乏使用大型,多样化,现实世界的数据库进行纵向分析.
- 了解当前的使用趋势对于供应链和临床实践管理至关重要.
研究的目的:
- 为了确定GLP-1受体激动剂产品的使用频率.
- 分析2型糖尿病 (T2D),心血管疾病 (CVD) 和超重/肥胖人口的使用模式.
- 估计单个GLP-1受体激动剂产品的月度生长率.
主要方法:
- 使用加利福尼亚大学健康数据仓库 (2014-2022) 的回顾性队列研究.
- 纳入标准:患者服用GLP-1受体激动剂.
- 使用逻辑线性回归模型估计的指数增长率.
主要成果:
- 欧森皮克 (Ozempic),韦格维 (Wegovy) 和蒙贾罗 (Mounjaro) 在2019年至2022年期间,用户数量显著增加.
- 在使用方面,Ozempic超过了Trulicity,特别是在超重/肥胖组.
- 在Mounjaro (254.3%),Wegovy (119.2%) 和Ozempic (83.9%) 发现了较高的月度增长率.
结论:
- 该研究揭示了GLP-1受体激动剂利用率的快速和可能持续增加.
- 这代表了这些药物使用的重大转变.
- 对基于证据的处方和供应链稳定性需要进一步的研究.
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