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Shuvasree Payra¹, Pramod Kumar Manjhi¹, Shruti Singh¹

¹Department of Pharmacology, All India Institute of Medical Sciences, Patna, India.

|October 11, 2023

概括

干细胞移植已经在几个人中治愈了艾滋病毒. 这涉及使用具有特定CCR5突变的捐赠者的干细胞,从而赋予HIV耐药性.

科学领域:

免疫学免疫学免疫学
病毒学病毒学
血液学血液学血液学

背景情况:

联合抗逆转录病毒疗法 (cART) 是艾滋病毒/艾滋病的标准,但不能保证完全治愈.
一名因血液性恶性瘤接受干细胞移植 (SCT) 的HIV阳性患者实现了这两种疾病的缓解.
这位患者成为第一个经过SCT后治愈艾滋病毒的记录病例.

研究的目的:

审查所有已记录的艾滋病毒治愈病例的最新信息.
探索HIV治疗研究的历史背景和关键里程碑.
讨论艾滋病毒治愈的潜在生物机制.

主要方法:

在PubMed,Cochrane图书馆和谷歌学者中进行了全面的文献搜索.
鉴定和分析了干细胞移植后治愈艾滋病毒的病例.
审查了涉及CRR5缺乏干细胞的拟议机制.

主要成果:

经过SCT治疗,有5例艾滋病毒治愈病例被记录在案.
一个常见的机制涉及捐赠体干细胞中的CCR5-delta 32 (CCR5△32) 同胞突变.
这种突变使宿主免疫细胞缺乏CCR5,防止HIV进入.

结论:

干细胞移植,特别是CCR5缺乏细胞的干细胞移植,为治愈艾滋病毒提供了潜在的途径.
对CCR5向疗法的进一步研究可以推进艾滋病毒根除策略.
了解这些病例为实现对艾滋病毒的功能治疗提供了关键的见解.

关键词:

CCR5 △32 △32 △32 △3 △3 △3 △3 △3 △3 △4 △3 △4 △4 △3 △4 △4 △4 △4 △5 △3 △4 △4 △5 △3 △4 △5 △3 △4 △4 △5 △3 △4 △4 △5 △3 △4 △5 △3 △6 △3 △3 △4 △3 △4 △4 △4 △5 △3 △4 △4 △4 △4 △5 △4 △4 △4 △4 △4 △4 △5 △4 △4 △4 △4 △4 △4 △4 △4 △4 △4 △4 △5 艾滋病毒治愈治愈艾滋病毒急性髓性白血病急性骨髓性白血病抗逆转录病毒药物治疗干细胞移植干细胞移植

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