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甲胺改善了精神分裂症患者的认知障碍:与背侧前额叶皮质功能连接的增强有关
Tiannan Shao1, Jing Huang1, Yuxin Zhao2,3
1Department of Psychiatry, National Clinical Research Center for Mental Disorders, and National Center for Mental Disorders, The Second Xiangya Hospital of Central South University, Changsha, 410011, Hunan, PR China.
甲胺显著改善了精神分裂症患者的认知功能和大脑连接,为与抗精神病药物使用相关的认知缺陷提供了新的治疗途径.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 药理学 药理学是指药理学的学科.
背景情况:
- 认知障碍是精神分裂症的主要症状,通常由抗精神病药物的代谢问题恶化.
- 与精神分裂症相关的认知缺陷的现有药理疗法有限.
- 以前的研究表明,甲福明在缓解抗精神病药物诱导的代谢障碍方面具有有效性.
研究的目的:
- 调查甲胺对精神分裂症患者认知障碍的影响.
- 检查甲胺对前额区域功能连接 (FC) 的影响.
- 评估认知改善,代谢变化和FC变化之间的关联.
主要方法:
- 一项开放标签,评估者盲目的研究,涉及临床稳定的精神分裂症患者.
- 患者随机分配,接受抗精神病药物加上甲福明 (N=48) 或单独抗精神病药物 (N=24) 24 周.
- 认知功能使用 MATRICS 共识认知电池 (MCCB) 进行评估;大脑FC使用voxel-wise 全脑分析评估,以背侧前额皮层 (DLPFC) 亚区域作为种子.
主要成果:
- 与对照组相比,甲胺组在MCCB复合得分,处理速度,工作记忆,口头学习和视觉学习方面表现得明显更好.
- 甲胺治疗导致DLPFC与前带皮质 (ACC) /中带皮质 (MCC) 之间的FC增加,并在DLPFC子区域内增加.
- 这些FC变化与认知表现正相关,并介导了处理速度和口头学习的改善.
结论:
- 梅特福林的使用可以改善精神分裂症患者的认知障碍.
- 甲福明的认知益处部分与前额头大脑区域的功能连接性改善有关.
- 甲胺是一种潜在的治疗药物,可以治疗精神分裂症患者的认知缺陷.
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