过热对肠道微生态,免疫功能和无进展生存期的影响,在患有晚期不可切割的肺腺癌的患者中
Jin Tian1, Lin Long1, Jianhua Zang1
1Oncology Center I Department, Qingdao Hiser Hospital Affiliated of Qingdao University (Qingdao Traditional Chinese Medicine Hospital), Shibei District, No. 4 Renmin Road, Qingdao, 266033, Shandong, China.
Scientific reports
|October 11, 2023
概括
在接受化疗和免疫治疗的肺腺癌患者中,高温改善了肠道微生态和免疫功能. 然而,它并没有显著地延长这一晚期癌症队列的无进展生存期.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 微生物组研究 微生物组研究
背景情况:
- 晚期不可切除的肺腺癌会带来重大治疗挑战.
- 优化标准化疗和免疫治疗方案对于患者的治疗结果至关重要.
- 超热在调节瘤微环境和宿主免疫力方面的作用需要进一步研究.
研究的目的:
- 评估高温对晚期肺腺癌患者肠道微生态,免疫功能和无进展生存 (PFS) 的影响.
- 为了比较接受标准治疗加高温症和单独接受标准治疗的患者的结果.
主要方法:
- 一项前性研究涉及40名患有晚期不可切除的肺腺癌的患者.
- 研究小组 (n=20) 接受了佩米特雷克斯德+西斯普拉丁+辛蒂利马布+高温症.
- 对照组 (n=20) 接受了佩米特雷克斯德 + 西斯普拉丁 + 辛蒂利马布.
- 通过16S rRNA基因测序分析肠道菌群;通过流细胞计 (T-淋巴细胞亚群,CD4/CD8比率) 评估免疫状态.
主要成果:
- 在各组之间观察到肠道菌群组成和结构的显著差异.
- 高热组在治疗后表现出改善的免疫功能 (T淋巴细胞亚群,CD4/CD8比率).
- 在高温和对照组之间没有发现无进展生存率的统计学上显著差异.
结论:
- 热量过高显著影响肠道微生态,并在接受化疗和免疫治疗的晚期肺腺癌患者中增强免疫功能.
- 作为辅助治疗的高温症在这个患者群体中没有显著延长无进展的生存期.
- 需要进一步的研究来探索高温症与新型癌症疗法结合的潜力.
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