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Updated: Jul 13, 2025

A Quantitative Measurement of Reactive Oxygen Species and Senescence-associated Secretory Phenotype in Normal Human Fibroblasts During Oncogene-induced Senescence
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在衰老过程中导致mtDNA释放,并驱动SASP

Stella Victorelli1,2, Hanna Salmonowicz1,2,3,4, James Chapman3

  • 1Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA.

Nature
|October 11, 2023
PubMed
概括

细胞衰老通过与衰老相关的分泌表型 (SASP) 触发与年龄相关的功能障碍. 在老化细胞中抑制线粒体外膜通透 (MOMP) 会减少炎症并延长小鼠的健康寿命.

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