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在前列腺切除术后的放射治疗中,患者特定的膀填充方案是否会影响膀体积和剂量?

Deniz Yalman¹, Murat Köylü², Özge Duran³

¹Department of Radiation Oncology, Ege University Medical Faculty, Izmir, Turkey. deniz.yalman@ege.edu.tr.

International urology and nephrology

|October 11, 2023

概括

使用超声波的患者特异性膀填充协议 (PSP) 在前列腺癌患者的放射治疗期间改善了膀体积的一致性. 这种方法在整个治疗过程中确保了最佳和可重复的膀填充.

科学领域:

辐射瘤学辐射瘤学
医学物理医学物理
泌尿器科泌尿器科泌尿器科泌尿器科

背景情况:

精确的膀体积管理对于前列腺切除术后患者的有效放射治疗至关重要.
标准的膀填充方案可以导致治疗期间膀体积的显著变化.
膀体积的变化可能会影响辐射剂量传递到有风险的器官.

研究的目的:

开发和评估一个患者特定的膀填充协议 (PSP) 使用基于超声波的膀扫描仪 (BS).
将PSP的体积和剂量参数与标准填充协议 (SP) 进行比较.
评估前列腺切除术后接受救援放射治疗的患者膀填充的可再生性.

主要方法:

在前列腺切除术后接受救援放射治疗的20名患者 (72 Gy/36 fx) 被招募.
PSP涉及基于超声波测量的个性化膀填充,以达到150-200cc体积.
标准方案 (SP) 依赖于患者对膀充满的主观感觉;使用计划CT和CBCT扫描的方案之间比较了体积和剂量数据.

主要成果:

与标准协议 (SP) 相比,患者特异性协议 (PSP) 显示了CBCT膀体积平均值的显著差异 (p=0.007).
在PSP组中,在计划CT和CBCT之间没有观察到平均膀体积或剂量的显著差异.
虽然SP显示了平均膀剂量变化的显著趋势 (p=0.074),PSP保持了一致的膀体积和剂量.

结论:

患者特定的膀填充方案 (PSP) 在整个放射治疗过程中有效地实现并保持了最佳的膀填充.
与标准方案相比,PSP在膀体积上表现出更好的可重复性.
这种超声波导向的方法在放射瘤学中为膀体积管理提供了一种可靠的方法.

关键词:

膀的填充膀的填充膀扫描仪膀扫描仪形光束计算机断层扫描前列腺癌是什么意思前列腺癌是什么意思辐射疗法辐射疗法

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