使用表面修改的V混合器减轻制药粉中的Tribocharging
Tanu Mehta1, Raj Mukherjee1, Ami Shah1
1Department of Pharmaceutical Sciences, University of Connecticut, Storrs, CT, USA.
Pharmaceutical research
|October 11, 2023
概括
表面修改的混合器显著降低了50%以上的制药粉中的静电电荷. 这项研究强调了材料选择和离散元件方法 (DEM) 建模,以改善粉末处理.
科学领域:
- 制药工程 制药工程
- 材料科学 材料科学 材料科学
- 粉末技术技术 粉末技术
背景情况:
- 固体剂型的制药制造严重依赖于粉末处理,静电充电是一个重大挑战.
- 大多数制药粉的绝缘特性导致电荷积累,阻碍有效的加工,并可能影响产品质量.
- 在大规模制造过程中,制药粉中的三元充电是关键问题.
研究的目的:
- 调查表面修改混合剂在降低药品粉末中的静电电荷方面的有效性.
- 为了分析 tribocharging 现象,使用一种新的表面修改混合器设计.
- 用一个计算的离散元件方法 (DEM) 模型来验证实验结果.
主要方法:
- 使用绝缘和导电材料的组合制造表面修改的混合机.
- 在不同的混合器 (,PVC,不钢,表面修饰的Al-PVC,SS-PVC) 中在20%的相对湿度下处理Ibuprofen粉末.
- 开发和验证一个离散元件方法 (DEM) 模型来模拟V混合器中的 tribocharging.
主要成果:
- 与传统的金属或仅用绝缘体的混合器相比,表面修改的混合器实现了Ibuprofen的静电电荷显著减少50%以上.
- 实验数据和DEM模拟结果显示了相同的充电趋势,证实了模型的准确性.
- 该研究表明,在混合机表面中组合不同的材料以减轻静电电荷的有效性.
结论:
- 仔细选择设备材料对于显著减少制药粉末中的静电电荷至关重要.
- 开发的离散元件方法 (DEM) 模型是评估修改混合器性能的一个有价值的工具.
- 混合设备的表面修改为在制药粉末加工中管理静电问题提供了实用解决方案.
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