患有第二期胃癌的老年患者不会从辅助化疗中受益
Jianping Guo1,2,3, Zhizhong Xiong1,2,3, Shi Yin1,2,3
1Department of General Surgery (Department of Gastrointestinal Surgery), The Sixth Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China.
World journal of surgical oncology
|October 11, 2023
概括
这项研究定义了75岁的老年胃癌 (EGC),该研究发现EGC患者的存活率较低,并且对II期疾病的辅助化疗没有益处.
科学领域:
- 在瘤学瘤学.
- 老年医学 老年医学
- 癌症研究 癌症研究
背景情况:
- 全球老年胃癌 (EGC) 的增加需要明确的定义和治疗策略.
- 目前关于EGC的定义和EGC患者II期辅助化疗的疗效缺乏共识.
研究的目的:
- 建立一个最佳的年龄界限来定义EGC.
- 评估辅助化疗在EGCII期患者中的有效性.
主要方法:
- 在三个独立的队列 (本地,SEER,ACRG) 中分析了5762名胃癌患者.
- K-自适应分区算法用于确定EGC的最佳年龄切线.
- 考克斯回归,卡普兰-梅尔生存分析和基因组变异分析 (GSVA) 来评估生存和途径丰富.
主要成果:
- 75岁的年龄被认为是定义EGC.最佳的最佳年龄.
- 在所有队列中,EGC患者的整体和癌症特异性存活率明显降低.
- 分层分析表明,EGC患者的辅助化疗对患者的益处很小,而改变的DNA修复和p53通路的潜在贡献很小.
结论:
- 在这项国际多中心研究中,75岁被提议为定义EGC的最佳年龄截止值.
- 辅助化疗对EGCII期患者没有好处.
相关概念视频
Peptic Ulcer Disease IV: Management
108
Medical treatment strategies for peptic ulcers encompass various methods. The primary goal of treatment is to diminish gastric acidity and strengthen mucosal defense mechanisms.
The therapeutic approach involves ensuring adequate rest, implementing drug therapy, promoting smoking cessation, making dietary modifications, and emphasizing long-term follow-up care.
Pharmacological management
The prevailing therapy for peptic ulcers involves a combination of managing the patient's current...
The therapeutic approach involves ensuring adequate rest, implementing drug therapy, promoting smoking cessation, making dietary modifications, and emphasizing long-term follow-up care.
Pharmacological management
The prevailing therapy for peptic ulcers involves a combination of managing the patient's current...
108
Nursing Ethical Principles II
1.0K
Ethical principles are essential in guiding nurses to fulfill their responsibilities, focusing on the quality of nursing care and decision-making. These principles, including autonomy, beneficence, non-maleficence, justice, and fidelity, shape the ethical framework within healthcare settings.
Consider the following scenario, which illustrates how these principles are applied in the care of Mr. John, a fifty-year-old teacher diagnosed with metastatic liver cancer.
Initially, Mr. John's...
Consider the following scenario, which illustrates how these principles are applied in the care of Mr. John, a fifty-year-old teacher diagnosed with metastatic liver cancer.
Initially, Mr. John's...
1.0K
Gastroesophageal Reflux Disease II: Clinical Features and Management
105
Gastroesophageal reflux disease, or GERD, is a persistent medical condition that affects many individuals worldwide. Its clinical manifestations can vary greatly, making diagnosis and management challenging for healthcare professionals. The following is a comprehensive overview of the clinical manifestations, assessment, and management strategies for GERD.
Clinical Manifestations
GERD presents itself in a multitude of ways, with symptoms varying from person to person. The hallmark symptoms are...
Clinical Manifestations
GERD presents itself in a multitude of ways, with symptoms varying from person to person. The hallmark symptoms are...
105
Barrett Esophagus-II: Clinical Manifestations and Management
170
Individuals with Barrett's esophagus are often asymptomatic, but they may experience symptoms commonly associated with GERD, such as heartburn and acid regurgitation. Additional symptoms can include difficulty swallowing, chest pain, unintentional weight loss, blood in the stool (which may appear black, tarry, or bloody), and episodes of vomiting.
To diagnose Barrett's esophagus, healthcare providers often recommend an endoscopy for those showing symptoms of acid reflux. The procedure...
To diagnose Barrett's esophagus, healthcare providers often recommend an endoscopy for those showing symptoms of acid reflux. The procedure...
170
Enteral Nutrition II: Nasointestinal and Gastrostomy Feeding
182
Enteral nutrition encompasses various methods of delivering nutrition directly to the gastrointestinal (GI) tract, bypassing traditional oral intake. It is particularly beneficial for patients who cannot eat by mouth but have a functioning digestive system. Key methods include nasointestinal feeding, gastrostomy, and jejunostomy, each suited to different clinical scenarios based on the patient's needs and condition.
Nasointestinal Feeding
Nasointestinal feeding involves placing a tube...
Nasointestinal Feeding
Nasointestinal feeding involves placing a tube...
182
Peptic Ulcer Disease V: Surgical Management and Nursing Care
321
Surgical management and nursing care are crucial in treating Peptic Ulcer Disease (PUD). Here is an organized and enhanced overview of the surgical interventions and the associated nursing care for PUD:
Surgical Interventions for Peptic Ulcer Disease
Surgical Interventions for Peptic Ulcer Disease
321


