从酸盐到NO:降酸盐细菌对全身健康和疾病的潜在影响
Hongyu Liu1, Yisheng Huang1, Mingshu Huang1
1Department of Oral Surgery, School of Stomatology, Southern Medical University, Guangzhou, China.
European journal of medical research
|October 11, 2023
概括
酸盐食补充剂通过肠道细菌增强氧化 (NO) 的产生,改善器官功能,并可能治疗疾病. 当内源性NO合成受到损害时,这种途径提供了一个重要的替代方案.
科学领域:
- 微生物学和人类生理学
- 专注于共生细菌在酸盐代谢中的作用及其对全身健康的影响.
背景情况:
- 酸盐 (DN) 补充剂在改善多系统疾病和器官功能方面显示出有前途.
- 具有亚酸还原酶活性 (NRA) 的共生细菌是关键的媒介,将食中的酸盐 (NO3-) 转化为酸盐 (NO2-),随后转化为氧化 (NO).
- 通过L-氨酸途径内源性NO生产在疾病状态中经常受到损害,这凸显了外源性NO3-/NO2-/NO途径的重要性.
研究的目的:
- 为了审查人类中含有酸盐减少酶的细菌.
- 强调微生物群代谢过程与宿主系统健康和疾病之间的关系.
- 突出降酸盐细菌在各种生理系统对人类健康的潜在影响.
主要方法:
- 文献综述总结了目前关于降酸盐细菌的研究.
- 对外部酸盐-酸盐-氧化路径的分析.
- 检查整个消化,心血管,内分泌,神经,呼吸和泌尿系统的疾病模型.
主要成果:
- 消化道中的酸盐减少细菌有助于将酸盐转化为氧化 (NO).
- 这种外源NO通路对生理活动至关重要,可以补偿内源NO生产受损.
- 不调节NO平衡与各种疾病有关,外源的NO生成可能减轻疾病的进展.
结论:
- 减少酸盐的细菌通过NO的产生和微生物平衡的调节,在宿主系统健康中发挥着重要作用.
- 外源性酸盐-酸盐-氧化物通路是NO生成的可行补充路径,对于恒温和疾病改善至关重要.
- 了解这些细菌为未来的疾病诊断和治疗提供了创新的策略.
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