OCOSO2:单盲,多中心,随机对照试验的研究方案,评估基于中央静脉氧和的目标导向治疗,以减少选择性大手术后高风险患者的术后并发症
Bruno Pastene1,2, Matthieu Bernat3, Karine Baumstark4
1Department of Anaesthesiology and Intensive Care Unit, Hôpital Nord, Hôpitaux Universitaires de Marseille, Marseille, France. bruno.pastene@ap-hm.fr.
这项研究调查了在重大手术期间使用中央静脉氧和 (ScvO2) 监测优化心脏输出是否可以减少术后并发症. 与标准实践相比,ScvO2引导的流体治疗旨在改善患者的治疗结果.
科学领域:
- 麻醉学和重症监护医学
- 外科手术患者管理
背景情况:
- 基于液体加载的目标导向治疗是大手术的标准,改善了结果.
- 目前的方法缺乏对心脏输出充足度的直接评估.
- 持续监测中心静脉氧和 (ScvO2) 提供了一种新的方法来评估手术期间的心脏输出.
研究的目的:
- 为了评估基于ScvO2的目标导向疗法是否可以在大手术期间优化心脏输出.
- 为了确定这种优化是否与标准流体治疗相比可以减少术后并发症.
主要方法:
- 未来的,随机的,单盲,多中心的受控优越性研究.
- 高风险的大型手术患者 (>50岁,ASA分数>2,手术>90分钟).
- 干预组:ScvO2引导的流体治疗;对照组:标准的流体治疗.
主要成果:
- 主要结局:术后第五天的综合并发症指数.
- 这项研究旨在证明SkvO2引导治疗的优越性.
结论:
- 这是第一个使用 ScvO2.2 评估目标导向疗法的心脏输出充足度的研究.
- 假设:ScvO2引导的流体治疗将减少大手术中的术后并发症.
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