在SARS-CoV-2感染后六个月的儿童的螺旋测量:单中心研究
Pothireddy Sharanya1, Devendra Mishra1, Anurag Agarwal1
1Department of Pediatrics, Maulana Azad Medical College and associated Lok Nayak Hospital, Delhi.
Indian pediatrics
|October 12, 2023
概括
三分之一的儿童经历了异常的肺功能,特别是在严重急性呼吸综合征冠状病毒2 (SARS-CoV-2) 感染后的六个月,强迫生命能力和强迫呼吸量减少. 体重不足的儿童有更高的几率这些异常的螺旋计结果.
科学领域:
- 儿科肺病学 儿科肺病学
- 传染性疾病 传染性疾病
- 呼吸系统医学 呼吸系统医学
背景情况:
- 严重急性呼吸系统综合征冠状病毒2 (SARS-CoV-2) 感染可以影响各种器官系统.
- 在SARS-CoV-2感染后儿童的长期呼吸系统后续需要进一步调查.
- 螺旋测量是评估肺功能的一个关键工具.
研究的目的:
- 在严重的SARS-CoV-2感染后六个月的儿童中评估螺旋测量参数.
- 为了确定与SARS-CoV-2后异常肺功能相关的潜在风险因素.
主要方法:
- 一个单一中心描述性研究,涉及40名儿童 (年龄在7-18岁) 感染SARS-CoV-2后六个月.
- 进行了螺旋测量,以测量1秒内强迫生命能力 (FVC) 和强迫呼气体积 (FEV1).
- 记录了临床病史和检查;统计分析确定了与螺旋计结果的关联.
主要成果:
- 30% (12/40) 的儿童表现出异常的螺旋计 (FVC <80%),其中83.3%的儿童也有FEV1 <80%.
- 体重不足的儿童具有显著更高的异常螺旋测量几率 (OR 5.13,P=0.028).
- 在异常的螺旋计和年龄,性别,感染严重程度或氧气需求之间没有发现显著的关联.
结论:
- 在SARS-CoV-2感染后的六个月随访时,三分之一的儿童有异常的螺旋测量结果.
- 体重不足状态是SARS-CoV-2后儿童肺功能受损的潜在危险因素.
- 需要进一步的研究,以了解SARS-CoV-2在儿童群体的长期呼吸道影响.
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