针对Delta和Omicron变种的SARS-CoV-2升而产生的子单位疫苗
Sheng Feng1, Zechang Fan2, Keyue Zhou1
1Changchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Changchun, China.
Journal of medical virology
|October 12, 2023
概括
一种新的SARS-CoV-2德尔塔变种候选疫苗 (Delta-6P-S) 显示出对多种变种的广泛保护. 这种新疫苗有效地减少了动物模型中的病毒载量和肺损伤,提供了有前途的广谱免疫力.
科学领域:
- 病毒学 病毒学
- 免疫学 免疫学 免疫学
- 疫苗开发 疫苗开发
背景情况:
- 目前针对SARS-CoV-2 (严重急性呼吸系统综合征冠状病毒2) 的疫苗对新兴变种的有效性降低.
- 对于提供针对不同SARS-CoV-2菌株的保护的广谱疫苗有着至关重要的需求.
研究的目的:
- 开发和评估一种基于SARS-CoV-2Delta菌株尖端蛋白的新型亚单元免疫原Delta-6P-S.
- 在临床前模型中评估Delta-6P-S候选疫苗对SARS-CoV-2变种的免疫性和保护性疗效.
主要方法:
- 一种稳定的前融合形状尖端蛋白 (Delta-6P-S) 经过六种普罗林突变而被设计出来.
- 免疫性和保护性有效性在小鼠和黄金鼠中使用辅助剂进行了评估.
- 进行了与SARS-CoV-2变种的中和化试验和挑战研究.
主要成果:
- 德尔塔-6P-S重组蛋白诱导了强大的免疫反应和针对多种SARS-CoV-2变体 (野生型,Beta,Delta,Omicron BA.1,BA.2,BA.5) 的交叉中和抗体.
- 与对照组相比,接种疫苗的黄金仓鼠在抽样,肺部和气管中显著减少了病毒RNA.
- 接种疫苗可以预防病理性肺损伤,并消除呼吸道中的传染性病毒.
结论:
- 德尔塔-6P-S子单元免疫原体显示出强大的免疫性和广泛的防护效果对抗SARS-CoV-2变种.
- 这种候选疫苗快速清除上下呼吸道的病毒复制.
- 德尔塔-6P-S值得进一步调查,因为它是一个有前途的广谱抗SARS-CoV-2疫苗.
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